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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of MTX for the Treatment of KRAS Mutant Colorectal Cancer

    SBC: Mekanistic Therapeutics, LLC            Topic: NCI

    PROJECT SUMMARY Mekanistic Therapeutics seeks to design discover and develop anti cancer agents that selectively inhibit multiple oncogenic pathways Its lead agent MTX was discovered in collaboration with the Leopold laboratory at University of Michigan MTX is a novel kinase inhibitor showing early promise for its therapeutic potential against solid cancers refractory to current treatm ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Commercial Software Using High throughput Computational Techniques to Improve Genome Analysis

    SBC: Genomenon, Inc.            Topic: 172

    Recent advances in DNA sequencing technology have not been matched by improved analytic techniques to quickly and accurately interpret patient genome data to inform diagnosis prognosis and therapy making decisions in the clinic and to identify candidate biomarkers of disease in research laboratories Development of automated techniques to facilitate interpretation of this data will benefit patien ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Regulators of NaV Channels Novel Anti Allodynic Drug Candidates

    SBC: Regulonix            Topic: 102

    PROJECT SUMMARY Chemotherapy induced peripheral neuropathy CIPN is a common prevalence and potentially dose limiting side effect of many cancer chemotherapy drug treatment regimens Clinically CIPN presents with pain that is burning shooting or electric shock like The increase in prevalence of cancer coupled with an increase in the cancer survival rates due to chemotherapy regimens ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A nanoparticle delivery system for CRISPR Cas based therapeutics

    SBC: ATGC Inc.            Topic: NCATS

    Abstract Applications of customizable nucleases such as CRISPR clustered regularly interspaced short palindromic repeats Cas CRISPR associated protein have enabled efficient and precise gene correction in vitro and hold promises for eventually achieving in vivo gene correction therapy However to apply CRISPR Cas in therapeutic settings several major challenges remain to be addressed ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Tessa Sleep Quality Monitoring

    SBC: EPITEL, INC.            Topic: NHLBI

    ABSTRACT TessaTM is validated medical device wearable capable of providing clinical sleep quality metrics for multiple nights to assess the efficacy of a sleep disorder treatment Tessa records the forehead EEG to stage sleep in an automated report that tracks changes in sleep architecture before and after a treatment for many sleep disorders such as obstructive sleep apnea and insomnia There is ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Dodecafluoropentane Prevents Ischemia Reperfusion Injury in Contemporary Acute Myocardial Infarction Management

    SBC: NUVOX PHARMA, L.L.C.            Topic: NHLBI

    Due to multiple factors time to administration of lytic therapy or emergent percutaneous coronary intervention PCI in acute ST segment elevation myocardial infarction STEMI may be delayed resulting in loss of additional myocardial tissue These delays are virtually impossible to overcome in remote regions and are associated with increased mor ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of the Building Efficacy for Successful Tapering BEST Program

    SBC: GOALISTICS, LLC            Topic: NIDA

    ABSTRACT Over million Americans suffer from chronic pain The use of chronic opioid therapy COT for pain has increased dramatically as have reports of opioid misuse abuse dangerous interactions with other drugs overdose and death As concerns over the alarming effects of COT have risen regulatory efforts have increased as well including medically supervised opioid tapering Tapering ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. HazPrep Worker Training Community Risk Profile

    SBC: Inxsol LLC            Topic: 142

    PROJECT SUMMARY ABSTRACT A workerandapos s personal hazard profile PHP is a function of hazards present and his her exposure level to those hazards Workers with an elevated level of risk are those who can be engaged in activities related to or working around hazardous materials waste generation removal containment transportation and emergency response inXsol believes two components a ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Hormonal Therapeutic for Retinopathy of Prematurity

    SBC: Zietchick Research Institute, LLC            Topic: W

    Whenever premature birth interrupts normal retinal vascularization of the developing eye retinopathy of prematurity ROP can occur When ROP was first reported in the s it was associated with high oxygen delivery to preterm infants Though oxygen delivery to preterm infants is now carefully regulated ROP is still a common occurrence In very low birthweight infants birth weights andlt ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Fc folate Conjugate for the Treatment of Triple Negative Breast Cancer

    SBC: NeuLink Inc.            Topic: 100

    Abstract According to the American Cancer Society in women in the U S will develop breast cancer at some point in their life and of these women will have triple negative breast cancer TNBC an aggressive subtype of breast cancer that lacks the three receptors ER PR HER that current drug treatment targets tamoxifen Herceptin Because of its aggressive nature and lack of effec ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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