Award Data

We will develop a commercial kit so that biologists can readily study tissues under conditions of hgradient culture. Here, as in nature, stratified epithelia adhere to their supporting stroma at a reRenewal of epithelium occurs adjacent to the interface, and all metabolic exchange is by diffusion aculture, a thin, transparent, permeable collagen membrane serves as a "stroma." Cells attach to oneth ...

We will design a unique device that would clean and recirculate indoor air for the purpose of contrtuberculosis bacilli and other micro-organisms. The device would be based on the principle of particimpaction, a well-understood mechanism which is very effective for particles greater than 1 micrometis adequate for the collection of airborne bacteria). An air-cleaning device based on these principc ...

The long term goal of this project is the development of synthetic peptide-based therapy for Humanlymphomas. The phase I period will serve (1) to test the feasibility of identifying peptide ligandsimmunoglobulin antigen receptors (IgR) from patients' tumors; and (2) to test the in vivo efficacy oligands in the SUP- B8 SCID mouse model system. The specific tasks to be accomplished are to 1) isolfro ...

We will develop rapid, cost-effective methods for detecting drug resistance in humanimmunodeficiency virus type l (HIV-l) isolates by analyzing the DNA sequences of patient samples. Thehealth of HIV-l/AIDS patients may be better maintained through lower toxicity and more appropriateantiviral use. All currently approved HIV-l antivirals are targeted against reverse transcriptase (RT).Specific mutat ...

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SIV infection of rhesus macaques serves as a valuable model for HIV infection in humans. Both virusthrough the CD4 T-lymphocyte receptor and are infectious and cytopathic for CD4+ T-lymphocytes and mviruses are genetically closely related: SIV shares approximately 50 percent homology with HIV-1 andhomology with HIV-2. In SIV- infected rhesus macaques, as in HIV-infected humans, a predominantly asi ...

A manufacturing process for the Vertical Cavity Surface Emitting Lasers (VCSELs) will be developed based on real time in situ monitoring and control. A fundamental challenge in spurring the wide acceptance of VCSELs lies in the development of a high yield crystal growth process. The study will focus on the following areas: the installation of complementary optical techniques such as pyrometric int ...

Long term objective is to purify DNA of fetal origin, starting with a sample of maternal blood. Thtechnology to be used with a variety of Diagnostic Methods including Polymerase Chain Reaction (PCR)Genomic Hybridization (CGH), Electrophoresis. The whole human genome becomes analyzable for a fetuswithout invading the fetus for a sample. Steps already available at Applied Imaging include enrichmea ...

A new approach to data entry, processing, and output is required which exploits the capabilitiesemerging in the microcomputer environment such as voice recognition, voice annotation, and imageprocessing, among others. Phase I objectives will be to develop and demonstrate a prototypeapplication of software for ethnographic research. The goals of the prototype will be to (l) propose anethnographic l ...