Award Data

The objective of this proposal is the creation of a method for identifying patients with hospital acquired C difficile infections likely to suffer expensive and potentially life threatening recurrences after discharge from the hospital C difficile has emerged as the biggest infectious killer of Americans as well as a multi billion drain on the health care system Most of those costs and mort ...

DESCRIPTION provided by applicant Glycans have several distinct properties that make their development as disease biomarkers appealing Firstly their location on cell surfaces makes them the first point of contact for cellular interactions and thus they are crucial in the control of normal metabolic processes and conversely they function as pathogen adhesion receptors Secondly specific gl ...

DESCRIPTION provided by applicant The ability to accurately quantitate the glycan chains attached to glycoproteins has wide ranging implications Numerous studies over the past years have demonstrated that abnormal glycosylation occurs in virtually all types of human cancers and demonstrate the potential of using glycan markers in either a diagnostic or a prognostic manner The glycosylatio ...

DESCRIPTION provided by applicant Ocular graft versus host disease O GVHD is a particularly severe and debilitating complication of allogeneic hematopoietic stem cell transplantation HSCT O GVHD develops in of patients with chronic GVHD Currently Restasis cyclosporine A is the only FDA approved prescription topical medication to treat O GVHD In Restasis had sales o ...

DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

DESCRIPTION provided by applicant The most common metastatic site for hormone refractory prostate cancer HRPC PCa is bone While docetaxel can prolong the overall survival in patients with metastatic HRPC current treatments do not provide a cure Further complicating the matter HRPC is a disease that affects a variety of patients differently which can be problematic for physicians to prov ...

DESCRIPTION provided by applicant We present a new family of contrast agents based on targeting the maltodextrin transporter termed maltodextrin based imaging probes MDPs which are designed to image infections associated with implanted medical devices by fluorescent imaging The chemical structure of an MDP is composed of maltodextrins conjugated to a fluorescent dye MDPs have the potentia ...

DESCRIPTION provided by applicant Currently there is no FDA approved therapeutic antibody capable of depleting long lived plasma cells A plasma cell specific monoclonal antibody could be used to treat plasma cell malignancies multiple myelomas which are fatal and for which there is no effective treatment and antibody mediated autoimmune and severe allergic disease e g systemic lupus e ...

DESCRIPTION provided by applicant The proposed project Directed Lineage Immunizations for Eliciting Broadly Neutralizing Antibody tests the directed lineage D L approach to HIV vaccination using clade C immunogens With a D L vaccine a series of progressively evolved Env immunogens are used to drive development of a broadly neutralizing antibody bnAb response which is important because ...

DESCRIPTION provided by applicant The objective of this project is to develop novel patient specific geometrically complex Titanium Ti alloy plates made by additive manufacturing AM also called D printing for foot and ankle applications These plates will offer superior fixation and mechanical performance while minimizing the plate bulk volume Foot and ankle surgeries are common wh ...