Award Data

Insulin-dependent diabetes mellitus affects millions of persons in the U.S. Despite years of intenseffectiveness of current therapeutic regimens remains limited due to the difficulty of duplicating thealthy pancreas. A potential method of treating this disease is the transplantation of allogenic orLangerhans. The most significant obstacle to the development of this approach is the immune rejectioI ...

There are currently no artificial polymeric vascular grafts with an internal diameter of less thanadequate long-term patency, with occlusion being due to a combination of thrombus formation and intiproject will improve the patency of such grafts by promoting rapid and stable transmural endothelialendothelialization process, capillaries from surrounding tissue invade the wall porosity of grafts ace ...

Infections are becoming a significant problem associated with the use of most types of medical devithe need for biomaterials with antimicrobial properties has gotten increasingly more important. Theis to develop an antimicrobial surface coating for central venous catheters using BSI's proprietarytechnology. This project will employ silver as the antimicrobial agent The Phase l objectives are torea ...

We will improve the fixation of non-cemented titanium hip prostheses by coating the porous surfacescollagens and growth factors. Two collagens (types I and IV) will be covalently coupled to the implapatented BSI photochemistry, and two growth factors will be non- covalently incorporated into each cmanner that slowly releases the GF's over several days. The collagen/GF coatings are expected to impo ...

We have developed a technology to efficiently produce high quality personalized audio cassette tapethis technology to test the clinical efficacy of a prototype personalized childhood asthma self-manaProgram objectives include determining how well such a personalized self-care system can improve a cpredict and self-control personal asthma triggers; 2) remember and initiate prescribed treatment; 3)r ...

The widespread occurrence of PCDD's in the environment in combination with their significant toxicicomprehensive assessment of their environmental impact. This assessment is made substantially more dthat the PCDD's are a mixture of 75 possible chloro-substituted derivatives, the most common of whicthe most significant environmental toxicants. Consequently, there is an acute need for the congenerPC ...

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Event Tracking Service (ETS) proposes to study the feasibility of developing a low cost ($50), self-contained, dual use, miniature, credit card size Environmental Measurement Device (EMD) to sense and log shock, vibration, temperature, and humidity. The device would be readily expandable to monitor other parameters. Our low power architecture includes 3V off-the-shelf CMOS electronics, a low power ...

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