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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Leptospirosis Vaccine Development

    SBC: Luna Bioscience, Inc.            Topic: NIAID

    Summary/abstract. Leptospirosis is a globally important neglected disease caused by pathogenic Leptospira. It is estimated to cause more than 1 million global cases annually with a 5-20% case-fatality rate, significant morbidity, and important public health consequences. Currently there is no safe and effective vaccine to prevent human leptospirosis. LeptoX, Inc. proposes to develop the first huma ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Treatment for Alcohol-associated Liver Disease

    SBC: MITOTHERAPEUTIX, LLC            Topic: 350

    Abstract The Specific Aim of this Phase I TTR proposal is to test the feasibility of our siRNA drug to ameliorate the pathology and progression of alcohol-associated liver disease (ALD). Alcohol consumption remains a leading cause of hepatic pathology worldwide and is one of the greatest sources of preventable morbidity and mortality. In the U.S., alcohol abuse impacts over 10 million individuals ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Technology to Disseminate WOOP (Wish, Outcome, Obstacle, Plan) to Dementia Caregivers

    SBC: BORROW MY GLASSES LLC            Topic: NIA

    1 Approximately 6.5 million Americans aged 65 and older live with dementia, supported by more than 11 million2 unpaid family caregivers. These numbers are projected to rise exponentially in the coming decades fueling the3 need to develop scalable ways to support dementia caregivers. The need to empower dementia caregivers to4 continue providing care while maintaining their own health and well-bein ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. A Self-Guided Mobile Intervention for Adults with Binge Eating and Obesity

    SBC: OUI THERAPEUTICS INC            Topic: 104

    ABSTRACT Obesity and comorbid binge eating are serious health problems for more than 40% of adults across the US.7 Health complications due to obesity comprise more than 20% of the nation’s healthcare budget, and the healthcare costs of individuals with binge eating are $18,152 higher than in obese peers without binge eating.13 The prevalence of binge eating and the substantial burden of healthc ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. T-cell receptor mimic affinity reagent generation using an in vivo novel immunogen strategy

    SBC: ABBRATECH INC.            Topic: 300

    ABSTRACT Current therapeutic antibodies target the cell surface and within the external cellular environment. Yet intracellular proteins make up half of the proteome. Having a facile means of targeting those intracellular proteins for the generation of therapeutic antibodies would be highly desirable. Targeting MHC complexed with neoantigens from intracellular proteins would greatly allow the gene ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Augmented Reality Personalized Motion Tracking Assessment and Improvement Technology for Fall Prevention for the Spanish Speaking Hispanic/Latino Population in a Community Setting Using Mobile Phone

    SBC: KINIMA, INC.            Topic: NIA

    More than 1 in 4 people 65 and older fall each year, leading to more than $50 billion in annual spending for treatment. This cost is on an upward trajectory. We have less understanding of the impact of falls and risk in the Spanish-speaking Hispanic/Latino population. Although a variety of community-based public health programs are addressing fall prevention, these programs are in English and are ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. PANK Activators for the treatment of pantothenate kinase-associated neurodegeneration

    SBC: Virtus Therapeutics Corporation            Topic: NINDS

    SUMMARY Pantothenate kinase-associated neurodegeneration, PKAN, is a rare progressive neurodegenerative disorder associated with iron accumulation in the brain. The disease causes early immobility and often death by early adulthood. PKAN is caused by mutations in one of four human pantothenate kinase genes, PANK2 gene, which encodes a mitochondrial pantothenate kinase. Consistent with the clinical ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a Novel Resolvin-Based Therapy for Treatment of Pancreatic Cancer

    SBC: Thetis Pharmaceuticals LLC            Topic: 102

    ABSTRACT Pancreatic cancer (PC) is a highly lethal disease with a 5-year survival rate between 5% and 10%. PC incidence and mortality are projected to more than double over the next ten years. However, existing systemic chemotherapies have limited efficacy along with significant side effects and safety issues, and targeted and immunotherapies have not been effective. Emerging data demonstrates tha ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Antifungals targeting pantothenate phosphorylation

    SBC: CURATIX, LLC            Topic: NIAID

    SUMMARY Invasive fungal infections (IFIs) create significant healthcare and economic burdens as they are responsible for more than one billion infections worldwide each year resulting in more than 1.5 million deaths. Hospital patients who acquire nosocomial IFIs experience longer hospital stays, increased morbidity, and higher mortality rates. Only a few classes of antifungal drugs are available, ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Engineering next generation supercharged CAR T-cells against solid tumors

    SBC: Cellinfinity Bio, Inc.            Topic: 102

    Project summary Adoptive cell therapy has revolutionized cancer treatment and has immense potential to cure a variety of cancer types. Multiple critical barriers exist for current CAR-T therapy particularly in solid tumor, including insufficient T cells trafficking to the cancer site, lack of effective cancer cell killing, severe toxicity, strong immunosuppression in the tumor microenvironment, an ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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