Award Data

PD/PI Kennard Brunson Project Summary Toward urinary catheterization with long-term resistance to bacterial colonization Problem: Catheter Associated Urinary Tract Infections (CAUTI) are one of the most common infections in hospitals and health care facilities. A study of urinary catheterisation involving over 9 million hospitalized patients found 12.9% were catheterised overall, but 72.9% were ca ...

PROJECT SUMMARY Opioid use disorder (OUD) is a major contributor to excessive disability, morbidity, and mortality in the United States. Currently, almost 10 million Americans misuse opioid substances and 2.7 million Americans suffer from OUD. In the past year alone, U.S. opioid overdose deaths have increased by nearly 30%, resulting in an annual mortality rate of rt100,000, akin to a death every ...

PROJECT SUMMARY Savior Brain’s SoftShox is the world’s first wearable hydraulic shock absorber. SoftShox uses liquid momentum transfer to dissipate impact energy, resulting in dramatically reduced linear and rotational forces for a given impact event. Brain injuries, including nearly 4 million concussions per year, are common among the nearly 40 million participants in organized youth sports i ...

SUMMARY Nonalcoholic steatohepatitis (NASH) is a significant, worldwide health problem affecting an estimated 14 million people in the US. It is characterized by hepatic inflammation and injury and fibrosis. Subjects diagnosed with NASH are at significantly increased risk of morbidity and mortality due to cirrhosis, and hepatocellular carcinoma. Without any currently available FDA approved treatme ...

Acute respiratory distress syndrome (ARDS) is a life-threatening condition featuring acute onset of non- cardiogenic respiratory failure and hypoxemia. Consequently, patients with ARDS have severe hypoxemia due to a significant impairment of gas exchange, and the goal of supportive therapy is to prevent critical tissue hypoxia, which can cause acute cardiac arrest and death or have long-term neuro ...

PROJECT SUMMARY/ABSTRACT Significance: EMPATHIE is a unique learning system that introduces healthcare and science concepts in an imaginative and engaging platform. The system combines an innovative motion-based game interface with software that provides an immersive experience into motor control disorders and promotes inquiry-based challenges. Importantly, lesson modules are presented to the stud ...

PROJECT SUMMARY/ABSTRACT Introduction: The Respiratory Oxygen Adherence Monitor (ROAM) system will provide an effective, practical, and affordable method to reliably assess and improve long-term-oxygen therapy (LTOT) adherence. Problem to be Addressed: Chronic obstructive pulmonary disease (COPD) over 15 people in the United States; the condition causes more than 500,000 hospitalizations and over ...

PROJECT SUMMARYAlzheimer’s Disease (AD) affects millions of Americans, yet there are no treatments that meaningfully affect disease progression once symptoms manifest. This has shifted the focus to early detection and intervention, which is thought by many researchers to offer the best chance of slowing or stopping the progression of AD. However, trials aimed at averting the underlying causes of ...

PROJECT SUMMARY Rotator cuff repairs are amongst the most performed orthopedic surgeries (rt400,000 surgeries in the US per year) but remain a very challenging clinical problem. While surgical repair of the rotator cuff seeks to improve shoulder function and stability, the surgical outcomes vary significantly because, pre-operatively, it is difficult under current evaluative methods to predict whi ...

Project Summary/Abstract Obesity-mediated insulin resistance is a hallmark of type 2 diabetes (T2D), which accounts for ~90% of all diabetes. Despite many drugs that are available to treat T2D, there is no FDA-approved drug that directly works on the insulin receptor (IR) to overcome insulin resistance. Recent studies show that galectin-3 (Gal3) can bind directly to the IR and inhibit downstream I ...