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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Newborn Screening for Sex Chromosome Disorders

    SBC: JS GENETICS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Turner syndrome (TS) is the most common genetic problem affecting women and occurs when an entire, or a portion of an X-chromosome is deleted. The incidence of TS 1 in 1,500 to 2,000 live female births. Features include primary hypogonadism, renal abnormalities and cardiac problems. Girls with TS are short and have an average adult height of 4 feet 6 inches. Ye ...

    STTR Phase II 2007 Department of Health and Human ServicesNational Institutes of Health
  2. dbVision: A Toolbox for bioimage databases

    SBC: MAYACHITRA, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This project brings together a strong interdisciplinary team of investigators to develop powerful image information processing and database tools for the exponentially growing bio-molecular image data, thus enabling a new generation of bio-image informatics. Contemporary microscopic techniques, including immunofluorescence microscopy, electron microscopy, GFP v ...

    STTR Phase II 2007 Department of Health and Human ServicesNational Institutes of Health
  3. Retroviral Vectors for Safe and Efficacious Gene Therapy

    SBC: Neumedicines Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Phase I funding for this project supported the successful development of the backbone for a new generation of retroviral gene therapy vectors that contain safety and efficacy features designed to overcome the problems that have been found with retroviral vectors used in current clinical trials. The model disease targeted is the well-studied genetic disease Aden ...

    STTR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  4. Software Leveraging a Standards-Based Web Service Framework for Decision Support

    SBC: RELIGENT, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Despite their demonstrated effectiveness, clinical decision support systems are not widely used to assist decision making in routine clinical practice. The long-range goal of this proposal is to make clinical decision support more available and more usable in healthcare through the further development and productization of a standards-based Web service framewor ...

    STTR Phase II 2007 Department of Health and Human ServicesNational Institutes of Health
  5. Reagents for Preparing Structure-Free DNA and RNA

    SBC: TRILINK BIOTECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Secondary structure in single-stranded ONA and RNA is a significant barrier to the efficient hybridization of short oligonucleotide probes. While some probes to a given target hybridize efficiently, other probes to the same target may not hybridize at all. Use of longer probes, on the order of 60 nucleotides in length, is one way to overcome this problem. Unfor ...

    STTR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  6. Live cell and HCS assays to quantify production of cardiomyocytes from stem cells

    SBC: VALA SCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Heart failure is a leading cause of mortality in modern society, and is the result from the death of cardiac myocytes. Contractile function of failing hearts can be restored by injecting the heart with embryonic stem cell-derived cardiac myocytes (ESCMs) which integrate into the host tissue. To facilitate production of ESCMs, high throughput screening systems a ...

    STTR Phase II 2007 Department of Health and Human ServicesNational Institutes of Health
  7. Impact of LifeSkills Training on Blood Pressure in Youth

    SBC: WILLIAMS LIFESKILLS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Essential hypertension (EH) has its pathobiologic origins in childhood. Since blood pressure (BP) ranking tracks from late childhood onward, adolescents with elevated BP are at risk for development of EH later in life. The need for development of effective primary prevention programs for EH highlighted the NHLBI is corroborated by recent BP rises in youth. The ...

    STTR Phase II 2007 Department of Health and Human ServicesNational Institutes of Health
  8. Automated Parkinson's Disease Dopamine Transporter Scan Analysis Fast Track

    SBC: MOLECULAR NEUROIMAGING, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): We hypothesize that for a class of dopamine transporter SPECT agents, an automated software processing package can be developed, which will objectively yield striatal quantitative uptake values for evaluating Parkinson's disease (PD) diagnosis and progression. This fully automated and Objective Striatal Analysis (OSA) package will be able to evaluate subjects r ...

    STTR Phase II 2007 Department of Health and Human ServicesNational Institutes of Health
  9. Novel Indication for Myeloid Progenitor Use: Induction of Tolerance in Solid Organ Transplantation

    SBC: Cellerant Therapeutics, Inc.            Topic: NIAID

    PROJECT SUMMARY State of the art techniques result inyear solid organ graft loss ofto overin cardiopulmonary organ transplantationEstablishment of donor specific immunological toleranceDSITa condition in which a recipient accepts a transplant without immunosuppressionwhile retaining the ability to fight infectionswould reduce graft loss and transplant related complicationsThe only identified metho ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. HLS- Cyclic CAR peptide: a targeted therapy for pulmonary hypertension

    SBC: VASCULAR BIOSCIENCES, INC.            Topic: NHLBI

    PUBLIC ABSTRACT This projectin response to announcement HLSdescribes a development program for CARSKNKDCCARa synthetic cyclic peptide that selectively targets diseased pulmonary vascular endothelium and enhances the therapeutic effect of vasodilator therapiesfor the treatment of pulmonary hypertensionPHPH is a disorder of elevated pulmonary vascular resistance characterized by progressive thickeni ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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