Award Data

DESCRIPTION (provided by applicant): Breast cancer is the most common form of cancer among women in the United States and is second only to lung cancer as the cause of cancer-related death; in 2007, more than 200,000 new cases of breast cancer were diagnosed and approximately 40,000 women died. The five-year survival rate for breast cancer is about 95% if the cancer has not spread at the time of ...

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DESCRIPTION (provided by applicant): Most organic pharmaceutical chemical syntheses are done in organic solvents. Oxygen and/or water contaminants in organic solvents will destroy many organic reactants and organometallic reagents and catalysts. As such, the removal of oxygen and water are critical to successful organic synthesis. Unfortunately both oxygen and water are ubiquitous and significant ...

DESCRIPTION (provided by applicant): Compact Membrane Systems, Inc. is proposing a revision to grant 1 R43 GM084478-01A1 entitled Contaminate Removal for Laboratory Pharmaceutical Synthesis in response to notice NOT-OD-09-058, NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications In this revision application, we are proposing to remove contaminants such as ...

A COMPUTERIZED DATABASE IS TO BE DEVELOPED TO MANAGE AN INTERVIEW SERVICE FOR CLIENTS OF AGENCIES OFFERING SERVICES TO THE ELDERLY. CASEWORKERS, PROMPTED BY THE DATABASE, WILL PERIODICALLY PHONE CLIENTS IN ORDER TO CHECK THEIR ONGOING HEALTH AND SOCIAL STATUS, TO RELAY TIMELY HEALTH INFORMATION. THE RESULTING PRODUCT WILL BE A COMPUTER PROGRAM AND A PROCEDURE FOR ITS USE WHICH SHOULD ALLOW MORE EF ...

DESCRIPTION (provided by applicant): Successfully delivering intensive yet safe gait therapy to individuals with significant walking deficits presents the greatest challenges to even the most skilled therapists. In the acute stages of many neurological injuries such as stroke, spinal cord injury, or traumatic brain injury, individuals often exhibit highly unstable walking patterns and poor enduran ...

DESCRIPTION (provided by applicant): The hepatitis C virus (HCV) infects approximately 4 million people in the U.S. The high mutation rate of HCV results in vast numbers of new genetic sequences and associated biological data in the daily conduct of laboratory research and clinical trials with attendant serious data management problems. Investigators currently rely upon homespun databases, generic ...

DESCRIPTION (provided by applicant): In the past two decades mutations in the mitochondrial genome were found to be responsible for a significant burden of human disease. More recently mtDNA mutations were shown to accumulate over time and may be responsible for some phenotypes of aging. Whereas DNA transfections into the nuclear genome are commonplace and have yielded great insight into biology, ...

DESCRIPTION (provided by applicant): Abstract this project tests the feasibility of a web-based measurement resource to support the work of scientists and practitioners studying child and adolescent drug use, and to increase the development and use of sound measurement practices. The product offers: 1) a measures database with information about measure characteristics, 2) a research collection doc ...

DESCRIPTION (provided by applicant): Chemoablation consists of applying a cytotoxic chemical agent via a needle (or needle-like system) directly to a target lesion in order to destroy it. This approach has gained clinical interest because it is a minimally invasive alternative treatment for tumors and it has the potential to minimize tissue trauma, increase local efficacy, and decrease side ef ...