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PROJECT SUMMARY ABSTRACT CairnSurgical LLC a Dartmouth spin off company will optimize and test the feasibility of a new image guided intervention device the Breast Cancer Locator BCL in breast conserving surgery BCS to i eliminate wire localization a moderately effective somewhat costly and certainly inconvenient procedure for patients and concomitantly to ii reduce positive ma ...

Despite the demonstrated benefit of CD targeted CAR T immunotherapeutics two challenges remain to bringing the therapeutics to market The first key challenge is to reproducibly manufacture the therapy so that the cellsandapos cytokine mediated function acts in a predictably consistent fashion post manufacturing The second key challenge is to manage the cellandapos s adverse effect immuno to ...

Tinea capitis scalp ringworm is a fungal dermatophyte infection of scalp hair follicles that afflicts of the U S pediatric population Tinea capitis is a major health care disparity because it occurs predominantly among individuals with a disadvantaged socioeconomic background and sub Saharan African descent Diagnosis of tinea capitis is currently dependent on culture and microscopy Both ...

DESCRIPTION provided by applicant Sickle cell disease SCD is a severe inherited disease that occurs in about in newborns in the U S greater than that of any other condition detected by newborn blood screening Only one treatment hydroxyurea is approved for the complications of SCD in adult patients Hydroxyurea is not approved in children due to concerns regarding possible genotoxi ...

DESCRIPTION provided by applicant Millions of children around the globe are afflicted with conditions that can alter neuropsychological development including human immunodeficiency virus HIV traumatic brain injury TBI cerebral malaria and a host of other developmental and acquired diseases and disorders Early assessment and intervention are critical in overcoming cognitive and deve ...

The goal of this project is to develop a lightweight and compact system that provides 51 percent oxygen enriched air at four to six liters per minute equivalent pure oxygen to individuals with chronic obstructive pulmonary disease (COPD). Existing systems may not deliver a high-enough supply of oxygen to support these individuals who may be capable of activity and for whom increased activity would ...

Decline in cognitive ability is a major quality of life problem for many cancer survivors This problem is affected bywhich treatments a particular individual receives Unfortunately research has provided little guidance on whichtreatment may be best for an individual based on unfavorable cognitive side effects To help researchers fill thisinformation gap and provide doctors and patients with t ...

Due to their exceptional properties, polyurethane coatings are used extensively in our society.Unfortunately, the socyanate-functional components used in the curing of polyurethanes are generally toxic. Thus, there is a need for polyurethane resins that can be cured without the use of isocyanate-functional components. In addition to enabling the production of polyurethane coatings that are free ...

NASA is considering multiple missions involving long-term cryogen storage in space. Liquid hydrogen and liquid oxygen are the typical cryogens as they provide the highest specific impulse of practical chemical propellants. These cryogens are stored at temperatures of nominally 20 K for hydrogen and 90 K for oxygen. Due to the large size of these tanks, refrigeration loads to maintain zero-boil- ...

NASA seeks new thermal control technology for EVA suits on Mars. The system must be closed-loop and non-venting, have negligible impact on the Martian environment, and be capable of operating under Mars surface conditions. We propose to develop a space evaporator/absorber/radiator (SEAR) system with innovative features that will enable operation on Mars. The system uses a regenerable water abso ...