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Project SummaryAlzheimer s diseaseADis expected to rise in prevalence fromtomillion Americans byleading toof deaths among adults overThis epidemic is projected to overwhelm healthcare and economic resourceswith costs reaching $billion in the US inand $trillion byThere is no cure for ADand no new drugs have been successful in treating the advanced stages of AD related dementiaA growing body of rese ...

PROJECT SUMMARYNucleosomesNucsare the repeating units of chromatinmade up of DNA wrapped around a histone octamerChanges in chromatin structurefunction can dramatically impact downstream gene expression and cellular physiologydriving oncogenic reprogramming and cancer progressionThis epigenetic regulation of chromatin is controlled by two major modificationshistone post translational modifications ...

PROJECT SUMMARYHistone methyltransferasesHMTsare a group of enzymes that represent a critical focal point in the linkage of cellular signals to the regulation of gene expressionThese proteins are not only strongly associated with numerous diseasese gcancersneurodegenerative diseasesand autoimmune disordersbut also have properties that make them excellent targets for drugsThusHMTs provide an except ...

ABSTRACTRedbud Labs proposes to develop a low costintegrated microfluidic system to purify and concentrate pathogens directly frommL of whole bloodwith the goal of improving the sensitivity of downstream blood culture and molecular diagnostic assays used in sepsis diagnosis and treatmentPhase I studies have demonstrated that our technologybased on actuated surface attached postsASAPscan achieve hi ...

Project SummaryAmong the commercially available systems for single cell isolation and next generation sequencingNGSsample preparationnone are capable of automating both imaging and NGS sample preparation at high throughputWhile single cell genomic analysis has improved in sensitivity and throughputconcomitant improvements in detailed phenotypic characterization of cells has not been integrated int ...

Project Summary Abstract Confusionbeing lostand losing track of oneandapos s orientation within large or unfamiliar indoor spacesthese are some of the biggest challenges facing people with visual disabilitiesSince GPS typically doesnandapos t work indoorsand isnandapos t fine grained enough anywayindividuals who cannot readily access visual information are at a significant disadvantageand many bli ...

The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. Some chemicals also can act directly on the skin including the vesicants sulfur mustard and lewisite. Early and rapid skin decontamination is extremely important following exposure to CWAs and TICs because it de ...

PROJECT SUMMARY ABSTRACT The National Research Council recognizes that serious computer games can support new inquiry based approaches to science instructionproviding virtual laboratories or field learning experiences that overcome practical and logistical constraints to student investigationsWith the nationally recognized need to encourage and enhance education in the ScienceTechnologyEngineering ...

PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

Two million laparotomies are performed annually in the U Swith ventral hernia being a frequent complication inof patients and costing as much as $billion annuallyThe ten year ventral hernia recurrence rate is reportedlywithout hernia mesh andwhen a mesh is added to the repair and these numbers underestimate recurrence rates in the rapidly growing morbidly obese population in the USIn Junein the La ...