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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. MyoRegulator: A non-invasive neuromodulation device for treatment of spasticity in stroke patients

    SBC: PATHMAKER MOBILITY CORP.            Topic: 101

    PROJECT SUMMARYABSTRACT Stroke affects overmillion patients in the U Swith an estimatedadditional cases of stroke occurring each yearOverof stroke survivors have spasticitya disorder of muscle tone that can cause striking impairments in functional movementPharmacologicalsurgical and physical treatments to manage spasticity haveat bestshort term efficacy and are confounded by side effectsIn this NI ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Small Molecule Treatments to Enhance Neurological Recovery After Stroke

    SBC: Stemetix, Inc.            Topic: NINDS

    PROJECT SUMMARYStroke is a major public health problem in the U Sand worldwideIt is defined as an area of brain damagegenerally due to the sudden occlusion of an artery in or leading to the brainStroke can cause weaknessnumbnessvisual disturbancespeech difficultybalance problemsand memory lossamong other symptomsWhile good treatments exist to limit stroke in the first few hours after occurrencefew ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Preclinical development of Novo29, a new antibiotic

    SBC: NOVOBIOTIC PHARMACEUTICALS, LLC            Topic: R

    Abstract The overall goal of this project is to conduct preclinical studies on Novoour newly discovered bactericidal compoundAs drug resistance continues to spreadnew classes of antibiotics are needed to combat infections by pathogens such as methicillin resistant Staphylococcus aureusMRSAand vancomycin resistant EnterococciVRENovois a novel class of peptidoglycan synthesis inhibitor with favorabl ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Discovery of Zika virus therapeutics using a replicon assay

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    ABSTRACT The Zika virusZIKVis the cause of an explosive pandemic of infections across South and Central Americathe Caribbeanand the southeastern region of the United StatesZIKV is a flavivirusa family of small positive strand RNA viruses that includes Dengue virusDENVWest Nile virusWNVYellow fever virusYFVand hepatitis C virusHCVZIKV is transmitted to humans by mosquitoes of the Aedes genusFor the ...

    STTR Phase I 2018 Department of Health and Human Services
  5. FAST platform for same-shift, complete antibiotic menu antibiotic susceptibility testing

    SBC: SeLux Diagnostics            Topic: R

    The goal of this Phase I SBIR proposal is to demonstrate utility to all major pathogenic bacterial strains of SeLux s rapidlow costphenotypic antibiotic susceptibility testASTsystemfast AST or FASTUtilizing existing optical detectors and standard dried antibiotic microplatesand avoiding pitfalls of metabolic probesFAST will potentially transform therapy of infections by significantly accelerating ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Humanized Anti-Renalase Antibodies for Unresectable Melanoma

    SBC: BESSOR PHARMA, LLC            Topic: 102

    Project Summary AbstractThis project brings together an experiencedintegrated project team with complementary expertise to advance a new approach to treating melanomas that cannot cured by surgery and have spread in the bodyThe project attacks a new targetrenalasean endogenous protein that can function as a survival factorwhich becomes overexpressed in melanomaand plays a role in suppressing the b ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Culture-free identification of pathogens common in endocarditis directly from patient specimens

    SBC: HELIXBIND INC.            Topic: NIAID

    PROJECT SUMMARY Infective EndocarditisIEis a life threatening disease that affects roughlyAmericans annuallyIE is characterized by microbial vegetations on the endocardial surface which induce serious heart damage and persistent bloodstream infectionsBSIsleading to sepsisLeft untreated IE is fatalAmong the criteria to establish IE and treat patients most effectivelyblood cultures are indispensable ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. CFI Pathogen Inactivation of Human Plasma Units

    SBC: APHIOS CORPORATION            Topic: NHLBI

    PROJECT SUMMARY The rapid spread of the Zika viruswhich can have a significant impact on neurological disorders in unborn fetuses and potentially adultsthe recent outbreak of the extremely virulent Ebola virusperiodic emergence of SARSrecurrent outbreaks of potentially pandemic strains of influenza such as H Nthe continuing epidemic of MERS and the worldwide AIDS epidemic have highlighted a persis ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Head mounted smartphone system for remote treatment of convergence insufficiency

    SBC: EYEPHONE LLC            Topic: NEI

    PROJECT SUMMARYIn this projectwe propose to develop and demonstrate feasibility of a head mounted smartphone based application forin home training and remote monitoring of progress for patients with convergence insufficiencyCICI develops in anestimatedofschool agechildrenintheU Soverallandcausessymptomsofeyestrainblurredvisionand reduced concentrationresulting in significant educational disadvanta ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Inhibitors of virus glycoprotein-LAMP1 receptor binding for Lassa virus therapy

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    Summary Since its discovery inLassa virusLASVa bi segmented RNA virus from the family Arenaviridaehas been recognized as the cause of disease affecting a quarter million people per yearresulting indeaths annually in West AfricaDue to global travelthere have been numerous confirmed cases of LASV infection outside West Africa including the USIts ability to spread as an aerosol and a case fatality ra ...

    SBIR Phase I 2018 Department of Health and Human Services

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