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CARDIOVASCULAR DISEASE IS THE LEADING CAUSE OF DEATHS IN THEUNITED STATES, CLAIMING NEARLY TWICE AS MANY LIVES AS CANCER. LASER ANGIOPLASTY HAS IMMENSE APPEAL, BUT A RELIABLE, PREDICTABLE SYSTEM HAS NOT YET BEEN DEVELOPED. RESEARCHERS HAVE CONDUCTED PRELIMINARY STUDIES TO DEMONSTRA-TE PREFERENTIAL ABSORPTION OF DYE LASER ENERGY BY ANTHERO- MATOUS PLAQUES WITH MINIMAL ABSORPTION BY NORMAL ARTERIAL ...

THIS PROPOSAL ADDRESSES THE PROBLEM OF TELEPHONE COMMUNICATION BY THE DEAF AND DEAF-BLIND. THE CURRENT STATE OF THE ART ALLOWS THESE PERSONS TO COMMUNICATE ON THE TELEPHONE WITH OTHERS WHEN BOTH ARE USING SPECIALIZED EQUIPMENT. THE PROPOSED CONCEPT WOULD REQUIRE SPECIALIZED EQUIPMENT BY THE HEARING-IMPAIRED PERSON ONLY. THE PROCESS IS BASED ON A COMMERCIAL MICROCOMPUTER CONVERTING TONE OR PULSE SI ...

FACTOR VIII IS THE PLASMA PROTEIN THAT IS FUNCTIONALLY DEFICIENT IN HEMOPHILIA A PATIENTS, RESULTING IN THE CLINICAL BLEEDING DISORDER. PATIENTS WITH THIS DISEASE REQUIRE FREQUENT INFUSIONS OF FACTOR VIII IN ORDER TO MAIN- TAIN HEMOSTASIS, PARTICULARLY DURING SURGERY OR FOLLOWING PHYSICAL TRAUMA. PRESENTLY, THE COMMERCIAL FACTOR VIII PRODUCT IS PURIFIED FROM POOLED BLOOD PLASMA OBTAINED FROM HUMAN ...

LOCALIZED AND SYSTEMIC MYCOSES CAUSED BY PATHOGENIC FUNGI (E.G., THE YEASTS CANDIDA ALBICANS AND CRYPTOCOCCUS NEOFORMANS) REPRESENT A SERIOUS HEALTH THREAT, ESPECIALLY TOIMMUNOCOMPROMISED PATIENTS AMONG WHOM INVASIVE CANDIDIASIS HAS HIGH MORBIDITY AND MORTALITY. CURRENTLY, IDENTIFICATIONOF FUNGAL PATHOGENS REQUIRES ISOLATION OF PURE CULTURES, FOLLOWED BY TESTING FOR SUBSTRATE ASSIMILATION AND FERM ...

NEW ANTITUMOR COMPOUNDS IDENTIFIED IN SCREENING PROGRAMS AREFREQUENTLY INEFFECTIVE AGAINST METASTATIC HUMAN TUMORS THAT EXHIBIT MULTIPLE-DRUG RESISTANCE. TO ENHANCE THE EFFICIENCYOF SCREENING FOR AGENTS LIKELY TO BE EFFECTIVE IN THE TREATMENT OF SUCH TUMORS, INTEGRATED GENETICS, INC. PROPOSESTO DEVELOP A DIAGNOSTIC PRODUCT CONSISTING OF A PANEL OF WELL-CHARACTERIZED, MULTIDRUG-RESISTANT DERIVATIVE ...

THE OBJECTIVE OF THIS PROGRAM IS THE DEVELOPMENT OF AN EXTRACORPOREAL PULSATILE ASSIST DEVICE (EPAD), A VALVELESS DIASTOLIC AUGMENTATION PUMP WITH VARIABLE STROKE VOLUMES UP TO 80 ML PER BEAT. THE EPAD IS DESIGNED AS A LOW-COST, DISPOSABLE DEVICE WHOSE INITIAL APPLICATION WILL BE AS A TEMPORARY RIGHT VENTRICULAR ASSIST DEVICE IN CONJUNCTION WITH THE USE OF A LEFT VENTRICULAR ASSIST DEVICE (LVAD) F ...

ROBOTICS IS BECOMING AN INCREASINGLY IMPORTANT FIELD IN RESEARCH AND MANUFACTURING. MOST ROBOTS, HOWEVER, EITHER PERFORM REPETITIVE PREPROGRAMMED OPERATIONS OR ARE GUIDED BY A HUMAN OPERATOR. THIS IS NOT PRACTICAL IN MANY APPLICATIONS WHERE AUTONOMOUS OPERATION IS REQUIRED, AND THE MOST IMPORTANT IMPROVEMENTS IN FUTURE GENERATIONS OF ROBOTS, ESPECIALLY FOR SPACE APPLICATIONS, WILL COME IN THE AREA ...

DURING OUR PHASE I PROGRAM, WE DEMONSTRATED A NOVEL APPROACHFOR INCREASING THE SURFACE AREAS OF MIXED METAL OXIDES OBTAINED FROM COMMERCIAL SOURCES. IN THE CASE OF LACO03, WEOBTAINED A SEVEN-FOLD INCREASE IN SURFACE AREA USING OUR NOVEL TECHNIQUE AND DEMONSTRATED THE MAINTENANCE OF THE PARENT PEROVSKITE STRUCTURE USING POWDER X-RAY DIFFRACTION. ADDITIONALLY, WE CONFIRMED AN INCREASE IN OXYGEN REDU ...

SOLID BORON HAS LONG BEEN RECOGNIZED AS A POTENTIAL HIGH VOLUMETRIC DENSITY PROPELLANT FOR VOLUME LIMITED ROCKET AND AIR BREATHING PROPULSION SYSTEMS. HOWEVER, ACHIEVING THIS POTENTIAL HAS BEEN DIFFICULT DUE TO LOW COMBUSTION AND HEAT RELEASE EFFICIENCIES IN CONVENTIONALLY DESIGNED COMBUSTORS. A THREE PHASE MODEL OF BORON ASSISTED COMBUSTION IS POSTULATED AND THE ROLE THAT KINETIC SENSITIVITY ANAL ...

THE ACTIVE SONARS TYPICALLY USED ON SUBMARINES OPERATE AT FREQUENCIES HIGH ENOUGH TO BE DIFFICULT IF NOT PRESENTLY IMPOSSIBLE TO MODEL ACCURATELY WITH FINITE ELEMENT ANALYSIS. LIKEWISE BEAM AND CYLINDER MODELS PROVIDE INADEQUATE REPRESENTATIONS OF THE HIGH FREQUENCY BEHAVIOR OF PLATE AND FRAME VIBRATIONS. THE APPLICATION OF THE AARC STATISTICAL ENERGY ANALYSIS PROGRAM WHICH INCLUDES BENDING, LONGI ...