Award Data

DESCRIPTION (provided by applicant): Malignant gliomas have a very poor prognosis with median survival measured in months rather than years. It is a disease with great need of novel therapeutic approaches. Within cancer gene therapy the use of adenoviral vectors to deliver HSV-tk (AdV-tk) has been one of the most widely studied and promising approaches. A few dose escalation Phase I studies ha ...

While individual instances of Chemical/Biological (CB) detection sensor technology development have progressed steadily, deficiencies remain. An integrated multi-sensor network for CB detection is a promising concept for improving performance. New development is needed to address the complex challenge of how to optimally deploy and evaluate CB sensor networks to ensure maximum utility against an e ...

Defense of U.S. space assets depends on the successful detection and monitoring of potential threats, including the ability to recognize abnormal spacecraft activities. Although work has been done in this area using resolved images from ground- and space-based sensors, methodologies to characterize unresolved resident space objects (RSO) have received little attention. We propose to develop tech ...

A system is proposed for real-time specification of the Battlespace Environment and integrated sensor management designed to optimize the joint operational capabilities of radio-frequency (RF), electro-optical (EO) and infrared (IR) sensors in the detection, tracking, surveillance, and characterization of space objects. To meet this objective, we present a framework for integrating phenomenologica ...

The complexity of Atmospheric Transport and Dispersion (ATD) modeling requires physically consistent weather data evolving in both space and time. Spatially and/or temporally averaged data found in climatological products is not suitable for ATD modeling. The proposed solution for providing "typical day" meteorological data couples innovative search techniques applied to long-range historical arch ...

Methane is the second most important atmospheric greenhouse gas after CO2, yet its global sources and sinks are still inadequately characterized. Recent observations that industrial plants may account for a substantial fraction of atmospheric methane have lead to an increased emphasis on studies of ecosystem CH4 fluxes, with particular interest in using isotopic composition to identify specific p ...

Recent enabling technologies are allowing Navy F18 strike aircraft and UAVs to work together fist-in-glove for close-quarters urban combat. Our proposal for TV2 (Targeting Video from VIVID) ties together these assets ever more effectively. TV2 remaps UAV target imagery into targeting imagery as will be seen from the F18’s targeting pod. This speeds F18 visual cueing and target confirmation. ...

Aerosol particles have important impacts on visibility, acid deposition, climate, and human health. A large fraction of the anthropogenic aerosol is generated from energy-related activities, and carbonaceous species are known to constitute a significant fraction of ambient aerosol mass in many locations. In particular, black carbon (BC), formed in combustion processes, is believed to have a stro ...

The chemical composition of the exhaust streams of aircraft engines (augmented and non-augmented) and combustors are required for the determination of combustion efficiency and for understanding pollutant formation. Typically, extractive sampling is used to measure aircraft emissions; however, these measurements are biased by chemistry that can occur as the gas sample travels through the probe and ...

The Army has identified solid oxide fuel cell (SOFC) power systems as a potential solution to a variety of power needs ranging from roughly 0.1 - 100 kW. Reformed JP-8, the Army logistics fuel, can be used as the feed, but the fuel sulfur content must first be reduced to 10 ppm. We plan to test a novel ultrasonic slurry reactor as part of a compact desulfurization process for treatment of sulfur ...