Award Data

The QuantiDNA RadTox System is a unique, patented technology that measures tissue damage shortly following injury using cell-free DNA from a drop of blood. Premised on murine and primate studies showing circulating DNA is logarithmically increased with whole-body radiation dose, RadTox has the potential to overcome many of the species-specific challenges faced by biomarker panels. The phase I SBIR ...

This proposal is to develop a novel slide based proximity assay platform to quantify protein phosphorylation on tissues. The novelty of this assay platform is derived from the use of the quantum dot with two emission peaks for fluorescence resonance energy transfer (FRET): one emission as internal standard and the other as FRET donor. Change of ratio of the two emission intensity during the FRET c ...

During this Phase I SBIR project, Electronic BioSicences (EBS) will develop a direct, long-read, RNA strand sequencing methodology that is capable of sequencing both canonical and specific modified nucleotides with high-accuracy. This will result in the development of technology wherein a single-stranded RNA (ssRNA) molecule is translocated through a nanopore reader using an applied voltage bias a ...

There is an increasing appreciation that dogs with naturally occurring cancers may be a better model system for evaluating cancer therapeutics than the traditional mouse model systems. However, use of dogs for evaluating the emerging class of immunotherapeutics for oncology is limited by the availability of suitable reagents to mentor the response of the canine immune system. The majority of reage ...

In this Fast track SBIR grant we aim, by the end of Phase II, to prepare and commercialize a fully humanized rat with Knock-out of many rat drug metabolism related CYP450's (9-in-9-out Rat Drug Metabolism-CYP450 Model) and Knock-in of the human counterpart. IN PHASE I we will develop an Active Genes: Gene Drive (AG:GD) rat - a rat with a properly configured Cas9 to power Active Genetics (AG); AND, ...

c Mycand KRas dependent cancerssuch as colorectal cancerrepresent major unmet medical needs that currently lack targeted therapyRecent scientific advances revealed that theseundruggableoncogenes critically depend on post translational modification with the small ubiquitin like modifierSUMOfamily of proteinsand inhibiting SUMOylation inhibits c Myc and KRasFurthermoreSUMOylation inhibition can acti ...

DESCRIPTIONprovided by applicantThe goal of this Fast Track SBIR is to demonstrate the functionality of PROFUSAandapos s novel injectable tissue oxygen monitors in patients with peripheral arterial diseasePADand to determine the its ability to detect restenosis in critical limb ischemiaCLIPAD is a manifestation of systemic atherosclerosis that affectsmillion people in the U Swith prevalence increa ...

PROJECT SUMMARY Elderly patients are the largest consumers of prescription and non prescription medications and have been reported to account for $million in treatment costs for medication errors likely due to altered pharmacokineticspolypharmacydecline in cognitionand lower health literacyAs a result of this confluence of issues that affect the aging populationmedication management tools designed ...

Project Summary Tobacco-attributable disease remains the largest potentially modifiable cause of mortality. Strategies to reduce smoking prevalence include developing more effective smoking cessation treatments. Nicotine metabolism and dependence are predictors of smoking behaviors, including response to smoking cessation treatments. The goal of this Phase II project is to develop prediction mode ...

PROJECT SUMMARY ! The abundance of airborne micron sized pollutant correlates with the prevalence and severity of respiratory diseaseswhich represents therd leading cause of death in the United States and have an economical cost of tens of billions of dollars per yearGrowing concerns on the possibility of terrorist attacks have motivated efforts in preparing for and responding to airborne releases ...