Award Data

The national imperative to field hypersonic weapon systems has increased the demand for robust, lightweight, and affordable high temperature materials for thermal protection systems.  Refractory composites such as carbon-carbon (C/C) or carbon/SiC (C/SiC) offer enormous promise, but wider-scale acceptance continues to be hindered by certain technical and affordability limitations.  Key among the ...

PROJECT SUMMARY/ABSTRACT In the United States, the postpartum period is a critical time for both maternal and child health; the US maternal mortality rate is the highest among other developed, high-income countries. More than half of all maternal deaths occur postpartum, from one day to one year after birth.1-9 There are vast racial and ethnic disparities in maternal mortality and severe morbidity ...

ABSTRACT The identification and removal of process-related protein impurities (PRPI) from biologic products is a critical step in drug development. Despite recent improvements in the purification and processing of biologics, the presence of immunogenic PRPI continue to raise concerns about drug safety and efficacy. We propose an innovative approach for assessing immunogenicity risk of PRPI using o ...

Summary Climate change is an urgent public health threat, and climate-related health risks disproportionately impact vulnerable populations. Public health agencies have underscored the need to develop scalable and innovative health-equity centered, multi-level interventions that offer tools and resources to 1) raise awareness of the inextricable link between climate change and health and 2) suppor ...

The goal of this Phase II SBIR is to extract latent or unexploited information from existing submarine acoustic sensors through a highly innovative inter- and intra-sensor correlation algorithm, in order to provide U.S. submarines with increased acoustic superiority over increasingly quiet adversaries.  U.S. adversaries are continuously improving their acoustic quieting technologies through effor ...

Estimating pose of missiles in flight from ground-based imagery presents a variety of challenges, such as low-resolution imagery, varying lighting conditions, cluttered background, and poor contrast between target and background. 3D models of the target object can simplify the problem by providing a strong constraint on the space of possible target poses. VSI proposes SkyLock, a robust and efficie ...

Satellite platforms play a critical role in the modern defense and intelligence infrastructure, providing timely, detailed, and readily available imagery to support U.S. national security. A fundamental requirement for this type of data is automated target detection and recognition, helping analysts to quickly locate and correctly identify targets of interest from vast quantities of image data. De ...

7. Project Summary/Abstract Over 11 million Americans are currently providing unpaid care to a family member or friend with Alzheimer's disease or a related dementia (ADRD). While caregiving can be a positive experience that brings meaning and an increased sense of purpose, it can also take a toll. Nearly 60% of ADRD caregivers rate their emotional distress as high or very high, and over 30% suffe ...

Propel proposes to conduct research in order to determine the performance level of a seamless cold weather mesh undershirt and drawers as compared to the existing undershirt and drawers.  Propel shall develop initial concepts and evaluate their technical feasibility.  Comparison to conventionally sewn seams using internationally recognized standards and test methods, as well as novel test method ...

Annular extruded plastics are in everything from fuel lines, hoses, pipes, and wires to catheters, medical tubing, and stents and makes up about ? of the $200B extruded plastics market. Extrusion manufacturing is a major processor of the $600B raw plastics industry, which produces 380 million metric tons of material each year. The production of these materials accounts for 4% of oil consumption an ...