Award Data

Modern pharmaceuticals have greatly improved the quality of life for many patients suffering a variety of illnesses. Unfortunately, among the 17 most commonly prescribed drugs, only 6 are highly effective for most patients, 5 have a modest effect, and 6 show little clinical effect. Worse still, unwanted illness and death from treatment of patients with the incorrect drug or dosage causes over 275, ...

7. Project Summary/AbstractC. difficile now causes more hospital-onset infections and deaths in the US than any other pathogen and is the most important cause of healthcare-associated diarrhea among adults in industrialized countries. In 2017, there were an estimated 462,100 combined healthcare- and community-associated C. difficile infection cases in the US, and 20,500 in-hospital deaths. In a ra ...

ABSTRACT The identification and removal of process-related protein impurities (PRPI) from biologic products is a critical step in drug development. Despite recent improvements in the purification and processing of biologics, the presence of immunogenic PRPI continue to raise concerns about drug safety and efficacy. We propose an innovative approach for assessing immunogenicity risk of PRPI using o ...

Project Summary/Abstract Enteral feeding (EF) is an essential medical procedure used to supply nutrients directly to the gastrointestinal (GI) tract of patients who are unable to eat independently. EF formula is often purchased as a ready-to-use liquid that contains carbohydrates, protein, fats, and micronutrients to ensure adequate nutritional benefit for the patient. The addition of therapeutic ...

Abstract Neuroene Therapeutics has discovered a novel class of well-tolerated, brain-penetrating, non-sedating compounds that are small analogs of Vitamin K (VK) that mimic the form of VK needed for mitochondrial and neurological health. Our VK analogs are effective in several animal models of pharmacoresistant seizures and Parkinson's disease. Our lead antiseizure drug (ASD) candidate is fast-act ...

Project Summary: The majority of cancer deaths are caused by dissemination and growth of secondary tumors throughout the body. While the 5-year survival rate for localized cancers has dramatically improved over the last four decades of drug development, the survival rates for cancer patients with advanced or metastatic disease remains abysmal, with median survival of Stage 4 patients at 10 months ...

Abstract Regenerative medicine therapies of various kinds are promising and rapidly growing, both in scale and type. The therapeutic products are not pills–they are living cells that are harvested from a patient (or sometimes a cell bank) and are shipped to a pharmaceutical company that modifies the cells and then sends them back to be re- injected into the patient. Logistics plays an outsize r ...

Summary/Abstract Among the most educationally valuable components of in-person 40-hour HAZMAT courses are team-based field exercises. This capstone activity combines skills and protocols into an experiential exercise in which learners practice different roles (e.g., entry team, decon team, site supervisor) and equipment (e.g., PPE, sensors, communications). Team-based HAZMAT training exercises hav ...

The US opioid crisis continues to have a catastrophic impact on human lives and the ongoing COVID-19 pandemic is compounding its effects. Based on the statistics published by the CDC, 91,799 drug overdose deaths occurred in the US in 2020, where the age-adjusted overdose deaths increased by 31% from 2019 to 2020. In addition, opioids, which cause respiratory depression, were involved in 75% of all ...

Project Summary Endometriosis affects 6-10% of women of reproductive age, with prevalence of 20-50% in infertile women, and 71-87% of women with chronic pain. The incidence of adenomyosis is reported as 28.9 per 10,000 women. Adenomyosis is detected in 27% of hysterectomy materials in benign gynecological surgery. It leads to abnormal uterine bleeding, pelvic pain, pelvic mass, and infertility. Ut ...