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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel Single Chain Antibodies against MIF for Prostate Cancer Therapy

    SBC: IBEX BIOSCIENCES, LLC            Topic: 102

    With the help of the National Cancer Institute we at Ibex Biosciences propose the following Phase SBIR project to evaluate novel camelid VHH antibodies that target macrophage migration inhibitory factor MIF for the treatment of solid tumors MIF is known to play prominent roles in the development of cancer and its expression in humans has shown to correlate with prostate cancer severity ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. High quality compact portable low field head MRI with ultra fast gradients

    SBC: Weinberg Medical Physics, Inc.            Topic: 108

    The company has shown that with by using ultra fast strong gradients inexpensive low field MRI systems can collect images that are comparable in quality signal to noise ratio resolution to conventional e g T MRI The company already has made large strides in commercializing this advantage by conducting human studies with a prototype and by attracting investors The prototype was built ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. PfSPZ Vaccines Quality Systems Manufacturing Regulatory and Clinical Quality and Data Management Support for Product Commercialization

    SBC: SANARIA INC.            Topic: NIAID

    ABSTRACT Sanaria s Plasmodium falciparum Pf sporozoite SPZ vaccines development program is receiving overwhelming global support Eleven trials of Sanaria s two primary PfSPZ vaccines which include subjects were initiated in late Tanzania U S or will start in early Kenya Ghana Equatorial Guinea EG Burkina Faso Germany and the U S These trials will assess to ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Facilitating Integration of HIV Prevention Strategies in Underserved Populations Through an mHealth Intervention

    SBC: RESEARCH CIRCLE ASSOCIATES            Topic: NIMHD

    ABSTRACT Each year there are at least new HIV infections in the United States African Americans who make up only percent of the U S population make up percent of the HIV positive population Latinos face three times the HIV infection rates as whites This circumstance occurs in an era of highly effective and tolerable treatment regimens for HIV that improve health prevent p ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Chemoenzymatic glycan remodeling of IVIG for improved anti inflammatory activity

    SBC: Glycot Therapeutics, LLC            Topic: 300

    Project Summary Abstract The goal of this proposal is to establish a robust and scalable process for production of specially engineered glycoforms of intravenous immunoglobulin IVIG with markedly enhanced anti inflammatory activity We propose to achieve this goal by exploiting a chemoenzymatic glycosylation remodeling technology IVIG is a mixture of antibodies prepared from the pooled sera of ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Directed evolution of N terminal amino acid binding proteins for application to protein sequencing

    SBC: Encodia, Inc            Topic: 300

    ABSTRACT including UNDERLYING PREMISE and STRATEGY to ENSURE ROBUSTNESS Our premise is that developing a better method for analyzing proteomes is required to take full advantage of the technological breakthroughs that have occurred in the last years in DNA sequencing We believe that the difficulties associated with previous proteome analysis methods can be overcome by using an entirely diff ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Highly specific HIV mRNA detection method with global subtype coverage to monitor latency reversal in patients

    SBC: Accelevir Diagnostics, LLC            Topic: NIAID

    Project Summary Abstract Human immunodeficiency virus type HIV is a retrovirus that infects CD T cells of the immune system If left untreated HIV infected individuals will progress to AIDS and may ultimately die as a result Combination antiretroviral therapy is extremely effective at stopping the replication of HIV in infected individuals Despite the success of this therapy at sup ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a next generation quantitative viral outgrowth assay QVOA for the standardized measurement of the HIV latent reservoir

    SBC: Accelevir Diagnostics, LLC            Topic: NIAID

    Project Summary Abstract Human immunodeficiency virus type HIV is a retrovirus that infects CD T cells of the immune system If left untreated HIV infected individuals will progress to AIDS and may ultimately die as a result Combination antiretroviral therapy is extremely effective at stopping the replication of HIV in infected individuals Despite the success of this therapy at sup ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Percutaneous Ultrasound Gastrostomy Development of a safer more affordable and more efficient method for feeding tube placement

    SBC: CoapTech, LLC            Topic: 300

    The goal of this project is to test a safer more accessible method for placement of gastrostomy feeding tubes Millions of patients worldwide require enteral nutrition and hundreds of thousands of gastrostomy feeding tube placement procedures are performed annually Key patient populations receiving gastrostomy procedures include Medicare enrollees in the United States pre term infants in dev ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Novel and Affordable Neoglycosylated Long Acting Superactive Analog of Human FSH for Infertility

    SBC: TROPHOGEN INC            Topic: NICHD

    PROJECT SUMMARY ABSTRACT It is estimated that over of all American couples suffer from infertility a topic of great importance to NICHD and cited frequently by this Institute Professional American women andamp those from all developed nations increasingly delay childbearing for several years compared to the past because of career advancement and increasing social acceptability This problem ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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