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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

Displaying 11 - 20 of 3340 results
  1. Topic 343- MindCap: Monitoring for Cognitive Impairment and Dyfunction in Cancer Patients

    SBC: Intelligent Automation, Inc.            Topic: NCI

    Persistent cognitive impairment is a frequent complaint of cancer patients undergoing chemotherapy. The current tests used to assess cognitive function are not sensitive enough to capture the degree of decline associated with cancer-related cognitive impairment (CRCI). In addition, they require professional administration and are subject to practice effects so they cannot practically be used for t ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. TOPIC 363- Caregiver Buddy: Leveraging Standards to Help Cancer Caregivers and Clinicians

    SBC: CARE PROGRESS, LLC            Topic: NCI

    This research project seeks to create innovative software that aids cancer patient caregivers,by improving their ability to access patient information, communicate with clinicians, and provide peer support. We seek to leverage the insights of stakeholders and subject matter experts as well as industry standards to enhance a caregiver facing SmartPhone app and related software developed in Phase I ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. An Engineered Nanoimmunotherapy for Melanoma

    SBC: ImmunoBlue, LLC            Topic: NCI

    PROJECT SUMMARY Melanoma is one of the most prevalent cancers and is estimated to account for overdeaths inin the United States aloneAlthough highly curable when detected earlytheyear survival rates decline precipitously for patients with regionaland metastaticmelanoma indicating a lack of efficacy of conventional therapiesand a strong need for novel therapies for this patient populationIn respons ...

    STTR Phase I 2018 Department of Health and Human Services
  4. Papillomavirus-like Particles (VLP) as Broad Spectrum Human Papillomavirus (HPV) Vaccines

    SBC: PATHOVAX, LLC            Topic: NIAID

    Project Summary The goal of this SBIR Fast Track project is to further the commercialization of PathoVax s bi valent RGVaxTM as a broad spectrum Human PapillomavirusHPVvaccine that targets all clinically relevant HPVsCurrent HPV vaccines provide type restricted protection that focuses only on sexually transmitted HPVs resulting in an unexpected STD stigma that directly affects uptake ratesBy targe ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Rapid automated polarizable multipole-based force field parameterization for accurate drug-receptor binding affinity calculations.

    SBC: DRUG DESIGN METHODOLOGIES, L.L.C.            Topic: 500

    PROJECT SUMMARY ABSTRACTDrug Design MethodologiesChris HoM DPh DThis SBIR will develop automated software to accurately estimate drug target binding affinity and selectivityThis capability is crucial to drug discoveryyet remains elusive in all current design toolsOur technology identifies favorable candidates and distinguishes problematic ones that could exhibit side effects due to weak or non sel ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Building an evidentiary case for circulating GHBP as a biomarker for drug-associated stunting of growth

    SBC: ReveraGen BioPharma, Inc.            Topic: NICHD

    There is increasing interest in the use of biomarkers in clinical drug developmentwith much of thest Century Cures Act focused on encouraging this approachIdeallybiomarkers could provide and acute and objective read out of drug mechanism of actionpharmacodynamic biomarkersor prediction of later clinical benefit or harmsurrogate outcome measureHoweververy few biomarkers have been validated for rout ...

    STTR Phase I 2018 Department of Health and Human Services
  7. Glycoengineering a bioconjugate vaccine against Klebsiella pneumoniae

    SBC: VaxNewMO            Topic: NIAID

    PROJECT SUMMARY Klebsiella pneumoniae is an increasingly prevalent drug resistant nosocomial pathogenCommonlyKpneumoniae isolates are carbapenem resistantwhich are referred to as carbapenem resistant EnterobacteriaceaeCREand present significantly less therapeutic intervention optionsFurthermorecommunity acquired infections associated with hypervirulent isolates of Kpneumoniae have emerged that are ...

    STTR Phase I 2018 Department of Health and Human Services
  8. Improved RSV F Vaccine Candidates


    Abstract Respiratory syncytial virusRSVa viral agent that causes severe respiratory illnessinfects a large percentage of infants and children worldwide by the age of threeEHeylen et alAccording to the CDCRSV is responsible for overhospitalizations andmillion outpatient visits among children younger thanyears as well ashospitalizations anddeaths among the elderly in the US aloneEKMilleret alAfter m ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Fast, flexible, and economical system for affinity-tag protein purification and tag removal

    SBC: POTOMAC AFFINITY PROTEIN, LLC            Topic: 300

    Project SummaryOur long term objective is to commercialize a fastsimpleflexibleand economical system for affinity tag protein purification and tag removalThis technology was developed as a result of NIH funded studies on the foldingstability and enzymology of the Bacillus protease subtilisinThe transformative purification technology combines three componentsa regulatedhighly specific proteasePsubt ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Noninvasive placement and activation of deep-brain stimulating magnetic particles for reduction of drug-seeking behaviors

    SBC: Weinberg Medical Physics, Inc.            Topic: NIDA

    Abstract Deep brain stimulationDBSwith implantable electrodes has been used for reduction of ethanol abuse and drug seeking behaviors in EuropeThe use of such deep brain stimulation procedures has been problematic because of concerns about invasiveness of the procedureApplicant has developed a new noninvasive method of transporting magnetic particles directly to target sites within the brainWe pro ...

    STTR Phase I 2018 Department of Health and Human Services

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