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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Immunomodulatory Therapy for Diabetic Nephropathy

    SBC: APT THERAPEUTICS, INC.            Topic: 400

    Diabetic nephropathy DN is one of the most common microvascular complications of diabetes and the leading cause of end stage renal disease in Western and Asian countries The current medical management of diabetes to prevent its complications include tight glycemic control and strict management of blood pressure these established treatments delay the onset and the progression of DN however th ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Developing novel immunoassays specific for thyroid stimulating and TSH blocking autoantibodies

    SBC: MEDIOMICS, LLC            Topic: 200

    Graves disease GD is the most common cause of hyperthyroidism accounting for to percent of more than million cases of hyperthyroidism globally It is an autoimmune disorder caused by thyroid stimulating antibodies TSAbs which bind to the thyrotropin or thyroid stimulating hormone TSH receptor on the surface of a thyroid cell This leads to stimulation of the thyroid gland and ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. DEVELOPING NOVEL TOOLS FOR SITE SPECIFIC QUANTITATIVE ANALYSIS OF RNA MODIFICATIONS

    SBC: MEDIOMICS, LLC            Topic: NCI

    Although recent developments in highly sensitive technologies have revolutionized research on RNA modifications the available quantitative methods can be further improved Current methods include liquid chromatography tandem mass spectroscopy LC MS MS and next generation sequencing coupled with modification specific antibodies The LC MS MS method is not accessible to many researcher scientists ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. FDA COMPLIANT IMAGING INFORMATICS FOR CANCER RESEARCH

    SBC: Radiologics, Inc.            Topic: NCI

    Quantitative imaging has the potential to transform cancer research and diagnostics The National Cancer Instituterecently funded the Integrative Imaging Informatics for Cancer Research I CR a year grant at Washington UniversitySchool of Medicine to develop advanced imaging informatics technology to enable this transformation I CR provides arange of imaging informatics capabilities to enable ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Scalable amperometric microchip array for high throughput screening of small molecules peptides or genetic perturbations for modulation of quantal transmitter release

    SBC: EXOCYTRONICS, LLC            Topic: 101

    ` The goal of this project is the development of a scalable n x m electrochemical detector array platform with on chip amplifiers for massively parallel recordings of quantal transmitter release events The neurobiological process that this assay analyzes is the process of exocytosis and transmitter release Neurotransmitters and hormones are stored at high concentration in membrane bound organel ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Activate Silent and Cryptic Intact Fungal SM Gene Clusters through FACs for Novel Antibiotics Discovery

    SBC: Intact Genomics Inc.            Topic: NIAID

    PROJECT SUMMARY According to a CDC report antibiotic resistant infections are associated with deaths and million illnesses in the United States each year The estimated annual impact of antibiotic resistant infections on the national economy is $ billion in excess direct health care costs and in lost productivity from hospitalizations and sick days The emergence of drug resistant mic ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. A Search Engine for Heterogeneous Information Needs in the Clinical Workflow

    SBC: MEDSOCKET OF MISSOURI, INC.            Topic: NLM

    DESCRIPTION provided by applicant Modern clinical practices represent a prototypical information intensive distributed and collaborative environment where physicians struggle to find the right information at the right time to make effective clinical decisions The situation is exacerbated not only by federal guidelines and policies regarding compliance to clinical quality metrics and meaningf ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Human Apyrase Therapy for Acute Ischemic Stroke

    SBC: APT THERAPEUTICS, INC.            Topic: 105

    Principal Investigator Program Director Last First Middle Chen Ridong Abstract There remains a crucial unmet medical need in acute ischemic stroke AIS treatment Approximately of patients die within one year and are permanently disabled making AIS the fourth leading cause of death and the leading cause of adult disability in the USA with an estimated cost range of $ ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. IGF OT IGF A STAGE BASED MOBILE INTERVENTION FOR SUBSTANCE USE DISORDERS IN PRIMARY CARE N DA POP SEPTEMBER FEBRUARY BASE AWARD

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    Not Available

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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