Award Data

Many protein-based drugs have limited efficacy due to a short half-life or require intravenous delivery because of low bioavailability when given subcutaneously. Extend Biosciences is developing proprietary carrier molecules that will allow proteins to access a transport pathway for efficient delivery to the vascular space and then maintain a sustained presence in circulation. This would be of par ...

Protein manufacturing is of paramount importance to chemical and biological defense applications. High-throughput protein purification is a critical need for rapidly scaling the target protein product. Existing purification methods primarly rely on synthetic-resin based chromatography, which is time-consuming, labor-intensive, expensive, and consequently, ill-suited for developing rapid countermea ...

Busek Co. Inc. and Ionic Research Technologies, LLC propose to develop a novel carbon dioxide and water removal technology using ionic liquids for closed circuit self-contained breathing apparatus that will extend its operating lifetime, while simultaneously reducing overall weight and logistic burden. Ionic liquids offer unique characteristics including high capacity CO2 capture, tunable gas sel ...

Safe and efficient air ionization and filtration technology compatible to biodefense applications is of paramount importance. Current ionization methods are energy-intensive, costly, prone to ozone generation, or inefficient, and consequently ill-suited for building protection applications. To overcome these issues, we propose to develop and demonstrate a novel bioaerosol ionization and collection ...

A prefilled auto-injector device for storing a beneficial agent in a dry and stable format alongside a diluent, and automatically delivering the beneficial agent to a patient after reconstitution. The device comprises an automatic needle insertion mechanism and automatic needle retraction mechanism and is safe and disabled after use. The primary drug container of the auto-injector is made from ...

In the event of an intentional or accidental release of ionizing radiation, it will be critical to have rapid triage assessment tools to evaluate the health of mission-critical personnel and to make effective use of available medical and emergency resources. However, assessment of whole body radiation dosage is challenging and established methods rely on visual manifestations, blood sampling and s ...

Junctional and inguinal bleeding is a significant and challenging problem on the battlefield. Inventors have developed new types of tourniquets, including the Abdominal Aortic Tourniquet (AAT) and the Combat Ready Clamp (CRoC) to address these abdominal and pelvic injuries. While these hemorrhage control technologies have been developed, validated, and approved for use, training systems that teach ...

The proposed simulation-based system will provide training in applying a wide variety of hemorrhage control technologies and techniques, especially those that have been developed to manage junctional and non-compressible hemorrhage. The initial focus will be to provide learning scenarios for use of direct pressure, packing, and use of the Combat-Ready Clamp (CRoC) and Abdominal Aortic Tourniquet ( ...

Deployed military medics and non-medic soldiers on the battlefield may be required to manage junctional and noncompressible hemorrhage. Devices such as the Combat Ready Clamp (CRoC) and abdominal aortic tourniquet have recently been developed and deployed to meet this requirement. There are currently no realistic training systems for these devices which can limit their effectiveness in the field. ...

Junctional and non-compressible bleeding is a life-threatening injury that requires immediate intervention. Therefore it is best to train even non-medics in the application of the life-saving methods to stop these hemorrhages. The ideal system would enable training on multiple injury types, react realistically to properly applied intervention, utilize the adjuncts as would be used in the field, ...