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SBC: Xona Microfluidics, Inc. Topic: 101
DESCRIPTIONprovided by applicantNeuron cell culture is widely used for studies in basic researchdrug discoveryand toxicity testingTraditional neuron cell culture approaches result in random growth of processes which prevent the study of their unique polarized morphologyOur goal is to provide robustuser friendlyand cost effective culture platforms to manipulate and access neurons and their subcellu ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: 7 Hills Pharma LLC Topic: NHLBI
PROJECT SUMMARY This proposal is in response to the parent announcement for Phase II STTR (R42) grant applications. Hematopoietic stem cell transplantation has become a preferred treatment for hematological malignancies and certain genetic disorders. Umbilical cord blood has become an appealing alternative to bone marrow or peripheral blood as a source of hematopoietic stem cells for transplant. D ...STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
SBC: ELGAVISH PARAMAGNETICS, INC. Topic: NHLBI
DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
SBC: PROFUSA, INC. Topic: NHLBI
DESCRIPTION provided by applicant Continuous biochemical monitoring has the power to change currently accepted standards of care shifting the emphasis from treating illness to maintaining health Point in time snapshots of a patientandapos s health can miss critical fluctuations or early warning signs that might warrant early interventions or changes in disease treatment and management PROFUS ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
Further Experimental Validation of a Fluid-Structure-Material Interaction (FSMI) Modeling and Simulation ToolsetSBC: ATA ENGINEERING, INC. Topic: AF17AT025
ATA Engineering, Inc. (ATA), partnered with a nonprofit research institution, CUBRC, Inc., (CUBRC), proposes a Phase II STTR project to further develop and continue validating a novel multiphysics simulation technology. The project team will implement the technology in a fluid-structure-material interaction (FSMI) software toolset that incorporates mutual interactions between aerodynamics and stru ...STTR Phase II 2020 Department of DefenseAir Force
SBC: CAPRICOR, INC. Topic: NHLBI
DESCRIPTION provided by applicant One of the most complex forms of congenital heart disease hypoplastic left heart syndrome HLHS affects an average of in every newborns with a mortality rate of up to percent during the first year of life The overall goal f our research is to develop safe and effective ways to improve short term and long term survival rates in babies born with HL ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: WECOSO, INC. Topic: MDA17T003
West Coast Solutions (WCS) proposes the development of the SSC-X Stirling cryocooler to enable the deployment of infrared (IR) payloads on small satellite platforms. We achieve extreme miniaturization (STTR Phase II 2019 Department of DefenseMissile Defense Agency
SBC: Radiant Creative Group, LLC Topic: NCI
DESCRIPTION (provided by applicant): In this Phase II STTR application, we will build upon work conducted in our successful Phase I project which established the technical merit, acceptability and feasibility of developing a Web-based intervention, MyFAP.org, for adolescents and young adults (AYAs) with familial adenomatous polyposis (FAP). The main research goal of Phase II is to evaluate the eff ...STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
SBC: MAINSTREAM ENGINEERING CORP Topic: AF121092
Forward-looking infrared seekers are the preferred guidance system for current and future hypersonic interceptors. Seeker performance is limited by the infrared window’s ability to survive and image in a high-Mach, endo-atmospheric environment where heating rates can exceed 80 W/cm². Window materials primarily fail because of thermal shock, but can also experience issues due to absorption/emiss ...STTR Phase II 2020 Department of DefenseMissile Defense Agency
SBC: Renova Therapeutics, Inc. Topic: NHLBI
DESCRIPTION provided by applicant Gene transfer for the treatment of cardiovascular diseases is bedeviled by inability to obtain safely and easily sufficient cardiac transgene expression Current methods of gene transfer for heart disease include intramuscular injection into heart muscle or intracoronary delivery approaches that are cumbersome to apply Consequently we have considered the u ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health