Award Data

There is an urgent need to bypass or cross the blood brain barrier (BBB) to deliver drugs for TBI treatment. This project aims to develop targted intranasally delivered, magnetically propulsed, and targted nanoparticles for traumatic brain injury (TBI). In Phase I, we will demonstrate the design, fabrication, and in vitro characterization of proposed drug laden magnetic nanoparticles as well as co ...

High-fidelity trajectory propagators are fundamental to the simulation and analysis of launch vehicles, missiles, and satellites. Applications in fields ranging from missile threat analysis to flightpath optimization seek fast and accurate solutions to large numbers of trajectories in federated simulation environments. Due to their robustness, well-known properties, and straightforward implementat ...

Optonicus proposes development of the TAP-LAM (Test Article Printing with Laser Additive Manufacturing for Threat Surrogate Target Production) powder bed fusion and directed energy depositions systems. The TAP-LAM metal additive manufacturing system will advance strategic missile defense system testing capabilities by improving 3D printing methods to rapidly produce large-scale threat surrogate ta ...

Metallic additive manufacturing (AM) is an attractive technology for the production of lethality test articles due to the potential for significantly reduced lead time and manufacturing cost.However, in order to be effective in providing accurate lethality data, the properties of the AM material have to match closely the properties of conventionally manufactured alloys found in real threat targets ...

Magnesium alloys have 35% lower density compared to aluminum, with improved temperature stability compared to high strength aluminum.They can also be fabricated with minimum gauge thicknesses considerably thinner than fiber composites, and are weldable, with much higher impact resistance.Traditional magnesium alloys, however, have had lower strengths than more developed aluminum alloys.Powder meta ...

This proposal is in response to the Defense Health Agency 2017 Phase I SBIR topic 17B-005.The approach is the use of a membrane oxygen pump using newly developed nano-thickness membranes with all the layers less than 1 micron total.Nanometer thickness membranes enable more oxygen output per surface area at temperatures of 300-600 C than current state-of-the -art 600-800 C membranes that are 50-300 ...

We will develop automatic ontology-aligning software, leveraging the enormous existing Cyc AI system to drive the formulation and ranking (pro/con argumentation) of hypotheses about term-term relationships, especially where the relationship is not simple 1-to-1 correspondence. Multiple Cyc micro-theories (contexts) will be created, to hold incommensurate alternative mappings, and logical conseque ...

OptTek Systems, Inc (OptTek), proposes an affordable, effective UQ capability for both legacy and new BMDS M & S. The OptTek Team includes research institution partner Oak Ridge National Laboratory (ORNL) and subcontractor RTSync Corporation (RTSync). The proposed BMDS M & S UQ capability maximizes insertability into existing and future MDA BMDS M & S-supported Event processes, analysis methods, a ...

IAI with University of Michigan proposes an innovative HIC software modeling and integration framework built around objectively quantified cognitive models of human operators i) Executive-Process/Interactive Control (EPIC) and ii) GOMS (Goal Operator Method and Selection rules) Language Evaluation and Analysis (GLEAN). The framework provides ability to model existing or futuristic operator workst ...

A goal of Uncertainty Quantification (UQ) is to use computer simulation of complex systems to make scientifically informed assessments for high-consequence decisions. Because end-to-end empirical data is difficult to obtain for the Ballistic Missile Defense System (BMDS), computer simulation provides the best method for understanding BMDS capabilities against a wide range of threats. Numerica Co ...