Award Data

The broader impact of this Small Business Technology Transfer (STTR) Phase I project is to enable a much wider adoption of various photomedical treatments. Broadly speaking, photomedical treatments use light to cure diseases and promote healing. Specifically, photodynamic therapy uses light to activate a photosensitizing chemical agent to kill cancer cells or bacterial with minimal side effects. M ...

The broader impact/commercial potential of this STTR project is to chemically recycle carbon dioxide, which would otherwise be released to the atmosphere, to useful fuels and products thus providing a closed loop for production and emissions for many common products. Virtually every industry uses petroleum and/or natural gas, either through transportation or plastics (e.g., packaging), and there i ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to develop a widely applicable, innovative pipeline for drug discovery against rare genetic disorders. While each orphan disease affects a small fraction of individuals, thousands exist, affecting 400 million people world-wide. The challenge to bring therapies to the clinics for diseases th ...

This Small Business Technology Transfer (STTR) Phase I project proposes to engineer butanol tolerance in the yeast Saccharomyces cerevisiae using a novel combinatorial genetic technology designed to enable yield enhancements in microbial production organisms. Microbial production of renewable fuels and chemicals is rapidly expanding. However, toxic products or by-products and engrained metabolic f ...

This Small Business Technology Transfer (STTR) Phase I project proposes to demonstrate the feasibility of software for the development of solutions to complex life science problems. Life science is truly an interdisciplinary field for which real collaborations can substantially advance the level of technology and product development. However, collaboration between industry and academic/government ...

This Small Business Technology Transfer (STTR) Phase I project proposes to combine a novel metabolically engineered Chinese hamster ovary (CHO) cell line with a unique, high performance, continuous cell-culture bioreactor to demonstrate the commercial viability of producing a bioengineered heparin from CHO cells. This CHO cell line overexpresses critical enzymes in the heparin biosynthesis pathway ...

This Small Business Technology Transfer (STTR) Phase I project proposes to develop a simulation and design software for droplet-based microfluidic devices. Designing microfluidic platforms for biological and biochemistry applications is a laborious process involving several experimental trials. Scaling up a basic design to a parallelized device is another challenge. As a result, computational tool ...

This Small Business Technology Transfer (STTR) Phase I project proposes to establish cost effective methodologies for the efficient production of catechins utilizing a microbial fermentation approach. Preliminary work on the biosynthesis of the catechins, using metabolically engineered Escherichia coli recombinant strains from their flavanone and phenylpropanoid acid precursors, has demonstrated f ...

This Small Business Technology Transfer Phase I project is titled ?Performance Optimization Toolbox for Wave Energy Conversion Devices?. Advanced wave prediction and concurrent online adjustment of the operating parameters (such as hydraulic system pressure and generator load) of existing wave energy conversion (WEC) devices have the potential to increase their power extraction efficiency by at le ...

This Small Business Technology Transfer Research (STTR) Phase I project aims to develop quantitative models of wind variability to aid the design of reliable, low-carbon electric grid systems with high wind penetration. All abundant renewable resources are naturally variable, creating a challenge for their integra¬tion onto an ?always on? electric grid. While this variability challenge is now beg ...