Award Data

The broader impact of this Small Business Technology Transfer (STTR) Phase I project is to enable a much wider adoption of various photomedical treatments. Broadly speaking, photomedical treatments use light to cure diseases and promote healing. Specifically, photodynamic therapy uses light to activate a photosensitizing chemical agent to kill cancer cells or bacterial with minimal side effects. M ...

The broader impact/commercial potential of this project is mainly in the area of machine condition monitoring. Vibration monitoring is an integral part of any machine condition monitoring regimen. All equipment that comprise belts, gears, bearings, drive motors, or other moving components have a specific vibration signature during normal operating cycles. Change in equipment vibration serves as an ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to develop a widely applicable, innovative pipeline for drug discovery against rare genetic disorders. While each orphan disease affects a small fraction of individuals, thousands exist, affecting 400 million people world-wide. The challenge to bring therapies to the clinics for diseases th ...

This Small Business Technology Transfer (STTR) Phase I project aims to apply computational protein design (CPD) to engineer polysaccharide monooxygenases (PMOs) for improved thermostability, so that a cocktail of PMOs and key cellulases will more efficiently convert lignocellulolosic biomass to fermentable sugars. The objectives of Phase I are to: (a) evaluate several natural PMOs for expression, ...

This Small Business Technology Transfer (STTR) Phase I project proposes to demonstrate the feasibility of software for the development of solutions to complex life science problems. Life science is truly an interdisciplinary field for which real collaborations can substantially advance the level of technology and product development. However, collaboration between industry and academic/government ...

This Small Business Technology Transfer (STTR) Phase I project proposes to develop a simulation and design software for droplet-based microfluidic devices. Designing microfluidic platforms for biological and biochemistry applications is a laborious process involving several experimental trials. Scaling up a basic design to a parallelized device is another challenge. As a result, computational tool ...

This Small Business Technology Transfer Phase I project is titled ?Performance Optimization Toolbox for Wave Energy Conversion Devices?. Advanced wave prediction and concurrent online adjustment of the operating parameters (such as hydraulic system pressure and generator load) of existing wave energy conversion (WEC) devices have the potential to increase their power extraction efficiency by at le ...

This Small Business Technology Transfer Research (STTR) Phase I project aims to develop quantitative models of wind variability to aid the design of reliable, low-carbon electric grid systems with high wind penetration. All abundant renewable resources are naturally variable, creating a challenge for their integra¬tion onto an ?always on? electric grid. While this variability challenge is now beg ...

This Small Business Innovation Research (SBIR) Phase I project is aimed at demonstrating commercial viability for a new self-healing corrosion-protection system. Corrosion significantly impacts both the costs and availability of commercial aircraft, costing tens of billions of dollars annually. The proposed Self-Healing Anti-Corrosion Coating (SHAC) is capable of repeatable repair and sustained pr ...

This Small Business Technology Transfer (STTR) Phase I project proposes to combine a novel metabolically engineered Chinese hamster ovary (CHO) cell line with a unique, high performance, continuous cell-culture bioreactor to demonstrate the commercial viability of producing a bioengineered heparin from CHO cells. This CHO cell line overexpresses critical enzymes in the heparin biosynthesis pathway ...