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SBC: KLEIN BUENDEL, INC. Topic: NIDA
DESCRIPTION (provided by applicant): Becoming a mother is a significant transition in a woman's life. This transition can precipitate major changes in health behaviors, like physical activity. Once a woman has a child she is much less likely to participate in regular, moderate to vigorous physical activity compared to women without children. Thus, new mothers are at risk for future weight gain and ...STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
SBC: ENGINEERING RESOURCES GROUP INC Topic: NIEHS
PROJECT SUMMARY Genomic instabilityinduced by DNA damageand partly mitigated by DNA repair and antioxidantsplays a critical role in the pathogenesis of many major human diseasessuch as neurodegenerationcancer and cardiovascular diseasetogether with agingThere is a critical need for automated assays that can perform these assessmentsand bring them into greater routine usewhich will help advance our ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: TUNITAS THERAPEUTICS, INC. Topic: NIAID
DESCRIPTION (provided by applicant): The goal of this proposal is to develop and commercialize a novel approach for allergen specific immunotherapy as treatment for severe food allergy. Food allergy affects about 3.5% of the US population and 6% to 8% of young children. It is clearly on the rise. Peanut allergy, which affects around 1% of the population, is among the most severe food allergies, r ...STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
SBC: Symic Bio, Inc. Topic: NIDDK
DESCRIPTION (provided by applicant): This proposal addresses PHS 2012-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]). More than 20 million American adults (1 in 10) have some level of chronic kidney disease (CDC), with a growing incidence in the aging population. Nearly 400,000 ESRD patients receive some form of dialysis, with t ...STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
SBC: CBT4CBT LLC Topic: R42
The goal of this fast track STTR proposal is to expand buprenorphine maintenance therapy for opioid dependent patients Over million people in the US are addicted to opiates Providing effective agonist therapy methadone or buprenorphine coupled with behavioral counseling greatly improves outcomes reduces morbidity and reduces societal costs Methadone maintenance treatment has been limit ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: Sersense Inc Topic: NICHD
ABSTRACT Premature infants are frequently at risk of infectionjaundice and hypoglycemiaconditions monitored by analysis of blood for c reactive proteinCRPbilirubin and glucose respectivelyTypicallymL of blood is drawn each time an infant is tested with multiple blood draws happening over the course of daysGiven that total blood volume of in premature infants ismLup toof blood volume may be lost du ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: PNEUMAX, LLC Topic: 113
PROJECT SUMMARYThree of top five causes of death in humans globally are lung relatedchronic obstructive pulmonary diseaseCOPDlower respiratory infections and lung cancers collectively account for over eight million deaths annuallyCurrentlyin preclinical settingstatic cell cultures and animal models are the most widely used systems for mechanistic and translational studiesHowevercritical limitation ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: MICROVI BIOTECH, INC. Topic: NIEHS
DESCRIPTION provided by applicant Hazardous compounds in waters and soils are subject to a complex dynamic web of interactions among physical chemical and biological constituents in the natural environment Computational modeling has been proven indispensable to hazardous substances remediation particularly integrated modeling of pollutant hydrogeological fate and transport For the first t ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: VLP BIOTECH, INC. Topic: NIAID
DESCRIPTION provided by applicant Overall Staphylococcus aureus is a gram positive bacteria which possesses a multitude of virulence factors It is a frequent and severe pathogen in hospitals and of increasing concern in the community where it results in severe skin infections pneumonia bacterial endocarditis and sepsis A significant proportion of these infections are the result of methici ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: ARCHIE MD INC. Topic: NHLBI
DESCRIPTION (provided by applicant): Informed consent has become an essential component of the doctor-patient interaction. The informed consent process requires that patients not only be given information about proposed medical treatment, but that it be presented in an understandable way so the patient can make meaningful choices about medical alternatives. At the heart of the informed consent doc ...STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health