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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. IONTOPHORETIC CATHETER RESEARCH

    SBC: Advanced Clinical Products Inc            Topic: N/A

    THE URINARY TRACT IS A MAJOR SITE OF NOSOCOMIAL INFECTIONS. THE LEADING CAUSE OF THESE INFECTIONS IS URINARY CATHETERIZATION, WHICH IN TURN IS THE MOST COMMON PREDISPOSING FACTOR FOR FATAL GRAM-NEGATIVE SEPSIS IN HOSPITALS. THE LONG-TERM OBJECTIVE OF IONTOPHORETIC CATHETER RESEARCH IS TO DEVELOP A DEVICE TO PREVENT CATHETER-RELATED URINARY TRACT INFECTIONS. THE ULTIMATE CONFIGURATION ENVISIONED CO ...

    SBIR Phase I 1987 Department of Health and Human Services
  2. IMMUNODIRECTABLE MR CONTRAST AGENTS

    SBC: ADVANCED MAGNETICS, INC.            Topic: N/A

    A NUMBER OF SYNTHESES OF SMALL MAGNETIC PARTICLES PERMITTINGTHE COVALENT ATTACHMENT OF ANTIBODIES WILL BE EXAMINED. CHANGES IN MAGNETIC RESONANCE (MR) PROTON RELAXATION AFTER MAGNETIC ANTIBODIES HAVE BOUND TO CELL SURFACE ANTIGENS WILLBE UTILIZED TO DEMONSTRATE THE BINDING OF ANTIBODY (AND MAGNETIC LABEL) TO ANTIGENS. THE MAGNETIC LABELS INVESTIGATED WILL POSESS THE MAGNETIC PROPERTIES OF A CRYSTA ...

    SBIR Phase I 1987 Department of Health and Human Services
  3. PRECISION SHOCK-WAVE GENERATOR FOR MEDICAL TREATMENT AND RESEARCH

    SBC: Advanced Technology & Research            Topic: N/A

    THIS INVESTIGATION INTENDS TO EVALUATE THE CAPABILITY OF AN ESTABLISHED SECTOR SHOCK-TUBE METHOD FOR APPLICATION TO LITHOTRIPSY. IT COULD PROVIDE A QUANTITATIVELY DEFINED SHOCK WAVE IN TERMS OF WAVE PRESSURE, DURATION, ENERGY, AND SPATIAL EXTENT FOR IMPROVED PATIENT TREATMENT AND USE OF SHOCK WAVES IN BIOLOGICAL RESEARCH. THE ONLY AUTHORIZED SHOCK-WAVE LITHOTRIPSY TREATMENT SYSTEM (DORNIER)EMPLOYS ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. SOLUTE-SOLVENT INTERACTIONS IN CHEMISTRY AND BIOLOGY

    SBC: Advanced Technology & Research            Topic: N/A

    THE "SOLVATOCHROMIC PARAMETER" DATABASE WILL BE EXPANDED ANDSOLUBILITY, DISTRIBUTION, AND TOXICOLOGY PROPERTIES (XYZ) OF ORGANIC NONELECTROLYTES WILL BE CORRELATED, RATIONALIZED,AND PREDICTED THROUGH LINEAR SOLVATION ENERGY RELATIONSHIPS OF THE FORM: XYZ = XYZ + MV/100 + S PI* + A ALPHA + B BETA, WHERE V IS A MEASURE OF SOLUTE (TOXICANT) MOLAR VOLUME, AND PI*, ALPHA, AND BETA ARE THE SOLVATOCHROMI ...

    SBIR Phase I 1987 Department of Health and Human Services
  5. 3-D DISPLAY OF VOLUMETRIC DATA UTILIZING ELECTRONIC AND HOLOGRAPHIC DISPLAYS WITH MOTION PARALLAX

    SBC: Aerodyne Research, Inc.            Topic: N/A

    MEDICAL IMAGING SYSTEMS ARE NOW PRODUCING IMAGERY OF SUCH COMPLEXITY THAT THE TRADITIONAL SLICE PRESENTATIONS ARE INSUFFICIENT FOR COMMUNICATING THE INFORMATION TO THE OBSERVER. CURRENT DISPLAY TECHNIQUES, SUCH AS PRODUCING 2-DPROJECTIONS OF 3-D DATA, ARE A STEP IN THE RIGHT DIRECTION. THIS PROGRAM IS CONCERNED WITH DEVELOPING TRUE 3-D DISPLAY SYSTEMS THAT INCLUDE STEREO AND MOTION PARALLAX. SPECI ...

    SBIR Phase I 1987 Department of Health and Human Services
  6. ASSAY FOR PREDICTING METHOTREXATE SENSITIVITY IN HUMAN BREAST CANCER

    SBC: Aeron Biotechnology, Inc.            Topic: N/A

    THE LONG-RANGE GOAL OF THIS PROPOSAL IS TO DEVELOP AN IN VITRO TEST TO IMPROVE SELECTION OF THERAPIES FOR INDIVD- UAL BREAST CANCER PATIENTS BY PREDICTING RESPONSE TO METHO- TREXATE. EXISTING ASSAYS FOR BREAST CANCER CELLS CANNOT DE-TERMINE METHOTREXATE SENSITIVITY BECAUSE OF REQUIREMENTS FORFOR FEEDER LAYERS AND MEDIUM COMPONENTS THAT CAN RESCUE SEN-SITIVE CELLS. THIS PROPOSA WILL,THEREFORE, EVAL ...

    SBIR Phase II 1987 Department of Health and Human Services
  7. CARRAGEENAN-STABILIZED COLLOIDAL GOLD BIOSENSOR ELECTRODES

    SBC: ALDERON BIOSCIENCES, INC.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  8. VENTRICULAR FUNCTION MONITOR FOR ACTIVE PATIENTS

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    TO INCREASE THE BASIC UNDERSTANDING OF THE CARDIAC FUNCTION TO IMPROVE TECHNIQUES TO AID IN THE DIAGNOSIS OF HEART DISEASE. WE PROPOSE TO CONDUCT RESEARCH ON AN IMPROVED METHOD OF EVALUATING MYOCARDIAL FUNCTION IN ACTIVE PATIENTS. THIS APPROACH INVOLVES THE USE OF A VERY COMPACT, VESTLIKE INSTRUMENT WHICH USES NUCLEAR MEDICINE TECHNIQUES TO MEASURE THE EJECTION FRACTION OF THE HIGH VENTRICLE ON A ...

    SBIR Phase II 1987 Department of Health and Human Services
  9. NEW 2D SOLID STATE X-RAY DETECTOR FOR BIOMEDICAL RESEARCH

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    TWO DIMENSIONAL X-RAY DETECTORS ARE FINDING INCREASING USE IN DIFFRACTION STUDIES OF BIOLOGICAL MACROMOLECULES, ESPECIALLY WITH THE ADVENT OF HIGH INTENSITY X-RAY SOURCES AND COMPUTER AIDED ANALYSIS SYSTEMS. CURRENTLY AVAILABLE DETECTORS ALL SUFFER FROM PERFORMANCE LIMITATIONS, MAINTENANCE REQUIREMENTS AND/OR EXORBITANT COSTS. THE PROPOSED RESEARCH IS AIMED AT THE DEVELOPMENT OF A LARGE AREA SINGL ...

    SBIR Phase II 1987 Department of Health and Human Services
  10. COMPUTER CONTROLLED COLLIMATORS FOR RADIATION THERAPY

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    ONE OF THE MOST IMPORTANT CRITERIA FOR SUCCESSFUL RADIATION THERAPY IS THE ABILITY TO DELIVER THE HIGHEST POSSIBLE TUMOR DOSE AND MINIMIZE THE DOSE TO NORMAL TISSUE. MOST TECHNIQUES CURRENTLY USED FOR SHAPING RADIATION THERAPY BEAMS INVOLVE THE FABRICATION OF CUSTOM MADE, DENSE ALLOY BLOCKS. WHILE THESE BLOCKS HAVE PROVEN TO BE RELATIVELY EFFECTIVE, THEIR CONSTRUCTION IS VERY LABOR INTENSIVE AND E ...

    SBIR Phase II 1987 Department of Health and Human Services

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