Award Data

PROJECT SUMMARY ABSTRACT The Occupational Safety and Health ActOSHAwas formed to protect workers and prevent work related injuriesOSHA standards include explicit safety and health training requirements to ensure that the workers have required skills and knowledge to do their work safelyBenten Technologies is partnering with the International Brotherhood of TeamstersIBTto help workers in the HAZMAT ...

Fluorescent nanoparticlesFNPare becoming increasingly popular in biomedical imaging and taggingCompared to molecule based fluorophoresFNP are typically brighter and more photostableThey can be functionalized with more than one tagging moleculeused for the tagging and tracing of specific moleculescellstissuesBrighter fluorescence facilitates more sensitive labelingand in many casesa lower limit of ...

Project SummaryOur objective is to develop small molecule inhibitors of the highly oncogenic protein tyrosine phosphatasePTP Aas a targeted therapy for ovarian cancerOvCaElevated levels of PTP AmRNA and protein in ovarian tumors correlate with disease progression and recurrencepoor patient prognosis and poor patient survivalGenetic depletion of PTP Ain cancer cells diminishes their ability to surv ...

Immunometabolic NLRXTherapeutics for IBD Biotherapeutics IncBTIis an emerging biotech company that synergistically combines the power of advanced computational modeling with translational experimentation to accelerate the development of novel products for precision medicine and healthThis SBIR application stems from data showing a vital role for nucleotide binding oligomerization domainleucine ric ...

Project Summary/Abstract Problem Hospitalization and prolonged immobilization often lead to the functional decline of vulnerable older persons. Bed rest and inactivity accelerate the functional changes that are part of normal aging; the link between inactivity and adverse outcomes is increasingly appreciated by medical professionals, and the mobilization of patients is a critical aspect of patient ...

PROJECT SUMMARY ABSTRACTThe unjust socialeconomicand environmental conditions that all African Americans face throughout their lives leads to pervasive health disparitiesSubstandard medical care due to systematic bias in the healthcare system and a substantial wealth gap between Black and White households all lead to poorer healthAnd yetthe association between race and health persists even when co ...

AbstractDiabetes is a public health threat and is theth leading cause of death among Hispanics in the United StatesThere are several risk behaviors that contribute to the development of diabetes including obesityphysical inactivityand poor dietHispanic adults are more likely to be affected by these risk behaviors compared to their White counterpartsIn additionincreased diabetes prevalence and risk ...

PROJECT SUMMARY Alzheimer s DiseaseADis expected to affectmillion people worldwide bybut as many as one third of these cases may be prevented by targeting modifiable risk factors such as dietphysical activitycognitive engagementand smokingNeurotrack TechnologiesInchas developed a digital multi domain lifestyle intervention for cognitive health designed to change behaviors associated with increased ...

The hypothesis for the proposed project is that inhibition of the classical complement pathway with Peptide Inhibitor of Complement C1 (PIC1) will be neuroprotective in a rat model of neonatal hypoxic-ischemic encephalopathy (HIE). HIE is an ischemia-reperfusion injury of the brain that occurs around the time of birth, with up to 60% mortality and 25% of survivors left with a significant disabilit ...

ABSTRACT This proposal addresses the clinical deficiency of the currently available oral treatments for hypothyroidism. Whereas levothyroxine (LT4, Synthroid® and other products) is the standard of care and effectively resolves symptoms in most patients, some hypothyroid patients are commonly treated with a combination of LT4 and liothyronine (LT3, Cytomel® and other products). LT3 has the disad ...