Award Data

More thanmillion Americans have such severe COPDchronic obstructive pulmonary diseasethat they cannot even climb a single flight of stairsdue to the feeling of suffocation with even minimal movementThese patients suffer like this for yearsfirst becoming essentially home boundthen chair boundand eventually bed boundThis lack of physical activity has been repeatedly shown to increase the frequency o ...

SUMMARY Sepsis is a clinical syndrome that complicates severe infectionSepsis remains the leading cause of morbidity and mortality in critically ill patientsThere are no specific FDA approved medicines for the treatment of sepsisCurrent concepts of the pathophysiology of sepsis suggest that organ failure and mortality in sepsis are caused by inappropriate regulation of the immune systemThis manife ...

Triple negative breast cancerTNBCis an orphan disease that attacksUS women every yearTNBC cells lack human estrogen receptorprogesterone receptorand epidermal growth factor receptorHerthe targets of existing medicinesTNBC recurs after standard of care chemotherapy and radiationkilling its victims withinyearsNew promising therapies such as poly ADP ribosepolymerasePARPinhibitors only benefit a smal ...

Project Summary This proposal builds upon the advances from the SBIR-Phase I program (R43GM123887), targeting the development of recombinant human MG53 (rhMG53), a novel tissue repair protein, as a topical therapeutic agent to facilitate healing of chronic wounds. Wound care represents a challenging problem to the public health, as no effective treatments for chronic non-healing wounds are availab ...

Inthe CDC designated carbapenem resistant EnterobacteriaceaeCREan Urgent Threatand inthe WHO designated it a Prioritycritical superbugAs few therapies remain to treat CREthe risk ofpanresistantCREuntreatable by any currently available antibioticincreasesEntirely new agents with novel mechanisms of actionMOAnot cross resistant to SOC agents languishOur proposal aims to develop an Oantigen biosynthe ...

The goal of this Phase II SBIR is to provide an efficient, engaging, and effective means to enhance parents’ ability to reduce prevalence of alcohol use and consequences, and other substance use through the development and evaluation of Parenting Now (PN). PN is a brief, interactive, self-paced, and digital curriculum for parents of high-school-aged adolescents, a frequently neglected population ...

PROJECT SUMMARY Preterm delivery is a leading cause of infant mortality and morbidity. It is estimated that annually about 15 million infants are born preterm. Across 184 countries, the rate of preterm birth ranges from 5% to 18%. In most countries, the rate of preterm birth has risen in the recent decades, and now preterm birth represents the most common cause of neonatal mortality. It is the sec ...

Project Summary / Abstract. We are developing an improved clinical method to treat patients with malignant pleural effusions (MPE), a serious condition that occurs in 150,00-175,000 patients in the US each year, affecting between 7 to 15% of all cancer patients. MPE results in an excessive accumulation of liquid in the pleural cavity, frequently leaving the patient to suffer from shortness of brea ...

More thanmillion U Sadults with typediabetesT DMdo not meet American Diabetes AssociationADAglycemic targets for glucose controlHealthcare costs related to diabetes were estimated at $billion inincluding $billion in direct medical costsPoorly regulated dietary intakewhich often results in chronic hyperglycemia and elevated HbA c levelscontributes substantially to this costAs suchmedical nutrition ...

PROJECT SUMMARY ABSTRACT This resubmission seeks to develop and establish our optical imaging agentPARPi FLas a new drug for margin assessment of high grade dysplasia and cancer of the cervix and vulvarThis new technology will allow non destructive and instant intraoperative margin assessment of surgically excised vulvar and cervical dysplasia specimens and early vulvar and cervical cancersSo farw ...