Award Data

CONTINUOUS BLOOD GAS AND PH MONITORING DEVICES DEVELOPED OVER THE PAST 20 YEARS HAVE FAILED, PRIMARILY DUE TO LACK OFSTABILITY AND THE ASSOCIATED DEPENDENCY ON THE CLINICAL LABORATORY FOR CALIBRATION. DEVELOPMENT OF A CONTINUOUS ELECTROLYTE MONITOR, OF PARTICULAR IMPORTANCE FOR NEONATAL AND INFANT MONITORING APPLICATIONS, HAS NOT BEEN ATTEMPTED. THE GOAL OF THIS PROJECT IS TO DEVELOP A COMMERCIALL ...

WITH THE INCREASING NUMBER OF PREMATURE INFANTS SURVIVING TO REACH BPD UNITS, ONE WONDERS HOW LONG THE SYSTEM CAN SURVIVE THE EXTREMELY HIGH COST OF LONG TERM CARE (ABOUT $700,000/YEAR IN THE BPD UNIT AND $300,000/YEAR FOR HOME CARE). ONE POSSIBLE ANSWER IS RELIABLE MONITORING OF PHYSIOLOGICAL VARIABLES WHICH PERMIT 1) MORE EFFECTIVE RESPIRATORY MANAGEMENT AND 2) MANAGEMENT BY LESS SOPHISTICATED C ...

DURING MOST SURGICAL PROCEDURES THE PATIENT IS PARALYZED AND MUST DEPEND COMPLETELY ON THE ANESTHESIOLOGIST TO MAINTAIN SUCH VITAL PHYSIOLOGIC FUNCTIONS AS BREATHING AND HEART RATE. IT IS THEREFORE NOT SURPRISING THAT WITH RELATIVELY FEW EFFECTIVE PHYSIOLOGICAL MONITORS AVAILABLE TO THE ANESTHESIOLOGIST, THE FREQUENCY OF MISHAPS IS HIGH. OF THE APPROXIMATELY 20 MILLION SURGICAL PROCEDURES PREFORME ...

ALTHOUG RENAL TRANSPLANTATION HAS PROVED TO BE BOTH USEFUL AND COST-EFFECTIVE COMPARED TO DIALYSIS, COMPLICATIONS ARE FREQUENT. MUST OF THE SUCCESS OF RENAL TRANSPLANTATION IS DEPENDENT UPON PROMPT IDENTIFICATION OF THE CAUSE OF IMPAIRMENT OF FUNCTION SO THAT APPROPRIATE TREATMENT CAN BE APPLIED BEFORE THE CONDITION BECOMES IRREVERSIBLE. ALTHOUGH NUCLEAR MEDICINE SYSTEMS AND SEVERAL METHODS OF ANA ...

A compact x-ray laser driver with a high repetition rate is the subject of this phase I project. Most existing x-ray laser drivers are huge (1000s of square feet of floor space), expensive ($10,000,000+), have a low repetition rate (1/hr), are complex and require several PhDs to keep them working. Thus applications of present x-ray lasers are limited. In contrast, the proposed laser will occupy on ...

BORON NEUTRON CAPTURE THERAPY (BNCT) OPTIMIZATION REQUIRES KNOWLEDGE OF TUMOR-BORON UPTAKE AND ELIMINATION KINETICS AND CONCENTRATIONS. AT PRESENT, THIS KNOWLEDGE IS OBTAINED THROUGH INVASIVE METHODS. THROUGH A NONINVASIVE METHOD, MULTIPLE DATA POINTS CAN BE OBTAINED OVER TIME WITHOUT DISTURBING THE BIOLOGICAL ENVIRONMENT. INITIAL STUDIES HAVE SHOWN THAT MAGNETIC RESONANCE IMAGING (MRI) CAN BE USE ...

WE WILL DEVELOP A NOVEL INSTRUMENT WHICH CAN SERVE AS A TELECOMMUNICATION DEVICE FOR THE HEARING OR SPEECH IMPAIRED, AND WHICH CAN ALSO SERVE AS A SPEECH SURRAGATE FOR PERSONAL COMMUNICATIONS. THE NEW DEVICE DIFFERS FROM EXISTING TDD'S PRIMARILY IN ITS EXTREME COMPACTNESS. THE DEVICE DIMENSIONS, WHEN FOLDED, SHOULD BE ABOUT 3"X4"X.6", WHICH WILL ALLOW IT TO BE CONVENIENTLY CARRIED THROUGHOUT EVERY ...

Although there have been many advances in optics for low energy x-rays, (

Sarcos is currently developing a technology that can lead to low-cost millimeter-scale gyroscopes, multi axis inertial sensors, and very compact laser scanning devices. This technology, called Micro Disk Systems (MDS), is based on levitating a small disk above a VLSI substrate using electrostatic fields. AC stabilization of the fields ensures that the disk position remains suitable, and field-base ...

THE PURPOSE OF THE PHASE I STUDY IS TO EXPLORE A NOVEL APPROACH FOR INFLUENZA VIRUS VACCINATION BY USING MICROENCAPSULATED ANTIGENS ADMINISTERED BY THE ORAL OR INTRANASAL ROUTE IN ORDER TO INDUCE A PROTECTIVE MUCOSAL IMMUNE RESPONSE. MICE WILL BE IMMUNIZED WITH PURIFIED INFLUENZA VIRUS TYPE A H3N2 (UDORN) FREE IN SOLUTION OR ENCAPSULATED IN BIODEGRADABLE MICROSPHERES, BY ORAL, INTRANASAL, OR SYSTE ...