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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. An antimicrobial-eluting bioresorbable bone filler for orthopaedic application

    SBC: CarMell Therapeutics Corporation            Topic: NIAMS

    DESCRIPTION (provided by applicant): The long-term goal of Carmell Therapeutics for this proposal is to develop a blood plasma-based biomaterial bone filler product that will elute antimicrobials to inhibit infection. Bacterial contamination is present perioperatively in 48-68% o all open wounds and 100% of severe open injuries. Per year in the U.S. ~ 123,000 open tibia fractures are contaminated, ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Coincident light/ultrasound therapy to treat acne vulgaris and atopic dermatitis

    SBC: SONIC TECH, INC.            Topic: NIAMS

    DESCRIPTION (provided by applicant): Sonic Tech Inc. is developing a unique energy-based therapy called CLENS (Coincident Light Energy and Non-focused ultraSound). Using two well-established clinical energy sources in a novel way, the technology is intended to treat dermal diseases caused by biofilms, a bacterially generated slime layer. Biofilms shield bacteria from attack by both antibiotics an ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Chemical optimization of a novel class of USP7 inhibitor for cancer treatment

    SBC: Progenra, Inc            Topic: NCI

    DESCRIPTION (provided by applicant): Many regulatory proteins are themselves tightly controlled by ubiquitin conjugating and deconjugating enzymes, whose dysfunctional forms are implicated in numerous diseases, including cancers. USP7, a deubiquitylating enzyme, regulates ubiquitylation and, thereby, stability of the E3 ligase HDM2, which in cells effects ubiquitylation and promotes proteasomal de ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Ubiquitin based therapy of aggressive cancer cell populations

    SBC: Progenra, Inc            Topic: NCI

    DESCRIPTION (provided by applicant): The degradation of most cellular proteins is regulated by coordinated addition and removal of ubiquitin by families of ubiquitin E3 ligases and deubiquitylating enzymes (DUBs) respectively. DUBs proteolytically cleave ubiquitin molecules from proteins resulting in modifications of protein activity, localization and function. Several DUBs are aberrantly regulate ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Optimization of bifunctional pharmacophores for the treatment of neuroblastoma.

    SBC: HARO PHARMACEUTICAL, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Genetic alterations that maintain cells in a poorly differentiated state are a hallmark of many leukemia and childhood cancers. Among them, neural crest-derived neuroblastoma is the most prevalent cancer in infants andthe most common extracranial solid tumor in children with the majority of patients being 5 years old or younger. Approximately 650 neuroblastoma ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. A Potent Small Molecule Chemokine Antagonist Blocks Tumor Cell Dissemination In V

    SBC: ALLIANCE DISCOVERY INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Evidence in pre-clinical and clinical settings suggests the involvement of chemokines in metastatic tumor cell disease spreading. We have recently provided data validating the involvement of the CX3CR1/Fractalkine axisin breast and prostate cancer metastasis. We have discovered a potent in vivo efficacious drug-like small molecule using in vitro chemotaxis and ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Nanobodies for detecting and manipulating A to I editing enzymes and their modified RNA products

    SBC: Abzyme Therapeutics, LLC            Topic: NIDA

    DESCRIPTION (provided by applicant): Adenosine to inosine or A-to-I RNA editing executed by ADAR family proteins is abundant in the central nervous system (CNS). The availability of tools to monitor and manipulate both ADAR enzymes and A-to-I RNA modifications will facilitate investigation of the relationships between specific A-to-I conversions and their function in CNS development. The goal of t ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Synthetic antibodies for monitoring modified RNAs

    SBC: ROCKLAND IMMUNOCHEMICALS, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): Post-transcriptional RNA modification plays an important role in biological processes. For example, adenosines to nosiness or A-to-I editing are most abundant in the central nervous system (CNS) and essential for normalCNS development. Presently, the available reagents for detection, quantitation, or immunoprecipitation of modified RNA are extremely limited. Ro ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Development of Salivary Analyte Stabilizers

    SBC: SALIMETRICS, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Saliva, like blood, contains a wealth of hormones, proteins and nucleic acid molecules that reflect physiological status; however, unlike other bodily fluids such as blood, salivary diagnostics offer an easy, inexpensive, safe, and non-invasive approach for biomarker identification, disease detection and drug monitoring, and have a high potential to revolutioni ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Salivary oxytocin as a biomarker for autism spectrum disorder

    SBC: SALIMETRICS, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Oxytocin is a secreted, peptide hormone that is involved in modulating a wide range of central and peripheral physiological responses. Most notably, it has been implicated in social behaviors, including parental behavior, the formation of social bonds, and the management of stressful experiences. Given the increased interest and important role of this peptide i ...

    SBIR Phase I 2014 Department of Health and Human Services

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