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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: Calista Therapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Enhancing longevity of implanted medical devices

    SBC: PIEZO ENERGY TECHNOLOGIES, L.L.C.            Topic: NIBIB

    DESCRIPTION provided by applicant Advanced methods for wirelessly recharging batteries for implanted medical devices are needed The useful lifetime of most implants is constrained by the longevity of the power source The goal of this program is to implement the development of an UltraSound Electrical Recharging system USerTM within a clinically deployed gastric sphincter stimulation system ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Detachable Nozzle Piezoelectric Dispense System for Cryo-TEM Sample Preparation

    SBC: ENGINEERING ARTS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Project Summary / Abstract Engineering Arts (EA) proposes the development of a detachable nozzle piezoelectric dispense system for use in Cryo-TEM (Cold - Transmission Electron Microscopy) sample preparation instrumentation. Cryo-TEM is an important tool for studying the structure of biological macromolecules in their native aqueous state. The challenging and l ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Rapid Histone Methyltransferase Profiling with Luminescent Reporters

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Human cells contain three billion base pairs of DNA, our genome, compacted into chromatin. Expression levels of proteins are controlled by chromatin structure through chemical modifications that provide a second layer of control beyond the DNA blueprint, collectively termed the epigenome. Alterations to the epigenome by methylation of histones and DNA are tight ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Targeted Comparative Gene Expression by Sequencing for Companion Diagnostics

    SBC: NUVOGEN RESEARCH, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): The long range goal of this project is to develop a high throughput method for companion diagnostics for cancer patients using next generation sequencing. It is a front end method compatible with all genome sequencing platforms, which preselects genes and labels samples in the first step to assure data integrity and to eliminate complexities of sequence analysi ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Kinome-wide cell-based assays

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Protein kinases serve as critical mediators of signal transduction in human cells and impact virtually all aspects of cellular physiology, from the coordination of the cell cycle and cell division to apoptosis. The deregulation of kinase mediated signaling is now known to be involved in a variety of human diseases that include, diabetes, inflammation, cardiovas ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Enabling Malarial Kinome Directed Drug Discovery

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: NIGMS

    DESCRIPTION (provided by applicant): World Health Organization (WHO) estimates that there are 154-289 million cases of malaria and 610,000-971,000 deaths each year. Malaria is caused by a protozoan parasite, Plasmodium, which is transmitted through the bite of a mosquito. In the absence of an effective vaccine against Malaria, chemotherapy remains the only viable treatment option. However with eme ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Mobile multifunctional tool for monitoring and management of respiratory diseases

    SBC: TF HEALTH CORPORATION            Topic: NHLBI

    DESCRIPTION (provided by applicant): Mobile multifunctional tool for monitoring and management of respiratory diseases Chronic Obstructive Pulmonary Disease (COPD) and asthma affect millions of people worldwide. Because there is no permanent cure for thesediseases, efficient management of the patients over their entire lifetime are needed, which becomes increasingly difficult with the rapid rise i ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Patient Breath Simulator for Capnometer Performance Verification

    SBC: WITTING INNOVATION LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Capnometers can fail in a number of ways that are not detectable using current static calibration testing procedures. These failures could include leaks in the sample line, a weak sample pump, inadequate dynamic response, flow restriction and flow obstruction. Failure of a capnometer during critical care procedures such as sedation and anesthesia can be life th ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Development of the Partner Pain Support Program

    SBC: GOALISTICS, LLC            Topic: NINR

    Abstract Chronic pain occurs in a social context, frequently impacting couples in a committed relationship. Most couples have a reciprocal influence on one another. Partners of people with chronic pain are both affected by pain and may play a (positive ornegative) role in pain management. Depending upon their skills and knowledge, partners may interfere with or facilitate coping with chronic pain ...

    SBIR Phase I 2014 Department of Health and Human Services

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