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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Rapid Histone Methyltransferase Profiling with Luminescent Reporters

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Human cells contain three billion base pairs of DNA, our genome, compacted into chromatin. Expression levels of proteins are controlled by chromatin structure through chemical modifications that provide a second layer of control beyond the DNA blueprint, collectively termed the epigenome. Alterations to the epigenome by methylation of histones and DNA are tight ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Targeted Comparative Gene Expression by Sequencing for Companion Diagnostics

    SBC: NUVOGEN RESEARCH, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): The long range goal of this project is to develop a high throughput method for companion diagnostics for cancer patients using next generation sequencing. It is a front end method compatible with all genome sequencing platforms, which preselects genes and labels samples in the first step to assure data integrity and to eliminate complexities of sequence analysi ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Kinome-wide cell-based assays

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Protein kinases serve as critical mediators of signal transduction in human cells and impact virtually all aspects of cellular physiology, from the coordination of the cell cycle and cell division to apoptosis. The deregulation of kinase mediated signaling is now known to be involved in a variety of human diseases that include, diabetes, inflammation, cardiovas ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Enabling Malarial Kinome Directed Drug Discovery

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: NIGMS

    DESCRIPTION (provided by applicant): World Health Organization (WHO) estimates that there are 154-289 million cases of malaria and 610,000-971,000 deaths each year. Malaria is caused by a protozoan parasite, Plasmodium, which is transmitted through the bite of a mosquito. In the absence of an effective vaccine against Malaria, chemotherapy remains the only viable treatment option. However with eme ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. Mobile multifunctional tool for monitoring and management of respiratory diseases

    SBC: TF HEALTH CORPORATION            Topic: NHLBI

    DESCRIPTION (provided by applicant): Mobile multifunctional tool for monitoring and management of respiratory diseases Chronic Obstructive Pulmonary Disease (COPD) and asthma affect millions of people worldwide. Because there is no permanent cure for thesediseases, efficient management of the patients over their entire lifetime are needed, which becomes increasingly difficult with the rapid rise i ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Patient Breath Simulator for Capnometer Performance Verification

    SBC: WITTING INNOVATION LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Capnometers can fail in a number of ways that are not detectable using current static calibration testing procedures. These failures could include leaks in the sample line, a weak sample pump, inadequate dynamic response, flow restriction and flow obstruction. Failure of a capnometer during critical care procedures such as sedation and anesthesia can be life th ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Development of the Partner Pain Support Program

    SBC: GOALISTICS, LLC            Topic: NINR

    Abstract Chronic pain occurs in a social context, frequently impacting couples in a committed relationship. Most couples have a reciprocal influence on one another. Partners of people with chronic pain are both affected by pain and may play a (positive ornegative) role in pain management. Depending upon their skills and knowledge, partners may interfere with or facilitate coping with chronic pain ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Inter-alpha-inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Improving Interlock Compliance with Computerized Education and Monitoring Systems

    SBC: AXXESS UNLIMITED, LLC            Topic: NIAAA

    Abstract All 50 States have enacted laws providing for alcohol ignition interlocks as a sanction for impaired driving. Going forward, interlock programs may become as widely use with impaired drivers than license suspension even though they are more time consuming and expensive for the government to manage. Although the extra expense of managing interlock programs is justified by the reductions in ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. HT Label-Free Screening and Kinetic Analysis of Small Molecules and Biologics

    SBC: Carterra, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Real-time label-free technologies such as surface plasmon resonance biosensors provide high-resolution information about the kinetics, affinity, stoichiometry, activity, and specificity, of two (or more) binding partners. While the application f biosensors is well established, current instrumentation has limited sampling throughput. Screens of even a fairly sma ...

    SBIR Phase I 2014 Department of Health and Human Services
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