Award Data

DESCRIPTION (provided by applicant): Accurate, early disease diagnosis and monitoring are critical aspects to effective prevention, treatment, and remission of disease. Most diagnostic methods available today are not simple or sensitive enough to significantly impact patients' response to treatment or survival outcome. This unmet need is highlighted by diseases, such as brain cancers, that o ...

DESCRIPTION (provided by applicant): Oncogenic KRAS is found in 25% of patient tumors across many cancer types. Despite extensive effort since its discovery over 30 years ago there is still no effective treatment for KRAS tumors. An estimated 350,000 patients in the US in 2013 will be diagnosed with mutated KRAS in their tumor, and many will die of their disease. Mutated KRAS plays a critical role ...

DESCRIPTION (provided by applicant): The American Cancer Society reports that death rates for melanoma have been rising in the United States for the past 30 years. It is one of the more common cancers in population younger than 30, and the most common cancer in adults ages 25 to 29. One characteristic of metastatic melanoma cells that is recognized as a potential target for new therapies is their ...

TeVido Project Summary/Abstract Globally, in 2010, there were slightly more than 1 million incidences of breast cancer. In the US ~200,000 women are diagnosed with breast cancer annually and nearly 40% will undergo mastectomies, full removal of the breast.In the US in 2010, more than 93,000 breast reconstructions were performed due to cancer. Patients with loss of the nipple areola complex (NAC) f ...

? DESCRIPTION (provided by applicant): Abstract Approximately half of the 1.6 million people diagnosed with cancer in 2013 in the United States will receive radiation therapy in the management of their disease. Because each course of radiation therapy is tailored to the disease and anatomy of the patient, delivery of the intended dose is dependent upon, in part, the ability of the treatm ...

DESCRIPTION (provided by applicant): Cancer is a significant health burden in the US and across the globe, representing the second leading cause of death in the US. Cancer cells have metabolic pathways that are altered significantly compared to normal cells. As a result, the pathways involved (lipid biosynthesis for example) are considered excellent targets for therapeutic intervention. The levels ...

DESCRIPTION (provided by applicant): We propose the development of Optic-speech, a system designed to use real-time animation of 3D models to visualize tongue movement during speech for use in guiding speech therapy for dysarthria. Approximately 3 millionAmericans suffer from dysarthria yearly, and the inability to speak can quickly lead to a reduced quality of life. Existing therapies can be inte ...

Project Summary We aim to introduce to the hearing-assistive device industry the first commercialized microphone that combines all three axes of acoustic pressure gradient onto a single silicon chip. We expect the technology to empower the signal-processing community with a new tool which, when used in conjunction with a conventional omnidirectional microphone, will facilitate new features like ul ...

DESCRIPTION (provided by applicant): GlycoMira Therapeutics has developed safe and effective anti-inflammatory glycosaminoglycan derivatives and proposes to test the feasibility of using its lead compound to treat or prevent oral mucositis. Mucositis is acommon and debilitating complication of cancer treatment. Cancer patients undergoing radiation or chemotherapy often develop this painful inflam ...

? DESCRIPTION (provided by applicant): Biofilms are the reservoirs for pathogens and colonize almost all surfaces, including those in the oral cavity; dental plaque is a complex biofilm. Oral biofilms cause periodontal problems commonly induced by acidogenesis and tooth demineralization by biofilm forming bacteria; dental plaque has been associated to and may lead to many serious systemic prob ...