List

DESCRIPTION (provided by applicant): The longterm goal of this project is to utilize cytomegalovirus (CMV) vectors carrying oncogenes of high risk human papillomaviruses (HPV) as novel therapeutic vaccines against cervical cancer. Although recently launched prophylactic vaccines protect against HPV infection, these VLP-based vaccines have not demonstrated significant benefit for individuals who a ...

PROJECT SUMMARY Depression and metabolic syndrome (MetS) are common chronic conditions that are debilitating to individuals and costly to employers and public and private payors.1-3 Unfortunately, they are often comorbid, each making the other more severe, more difficult to manage, and more costly.4-7 This project will create MoodJaunt, a mobile app designed to fill a well-known gap8-14 in the po ...

DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

? DESCRIPTION (provided by applicant): Non-variceal upper gastrointestinal bleeding (NVUGIB) is a major cause of morbidity and mortality worldwide. Incidence of NVUGIB in the US is 53 events per 100,000 adults, with approximately 160,000 hospital admissions annually. US treatment and prevention of NVUGIB continues to be a major medical emergency, costing 550-900 million dollars every year. Fai ...

DESCRIPTION (provided by applicant): Yecuris has developed an in vivo genetic selection system (the FRG KO mouse) that permits extensive humanization of murine liver by transplantation with human hepatocytes. This model has many potential commercial applications in drug development and testing, both in the in vivo and in vitro markets, .The mouse, however, is a small rodent and therefore the num ...

DESCRIPTION (provided by applicant): This Phase I proposal is to develop audio-tactile reading technologies. These should greatly improve access by blind people to typical graphs, charts, and diagrams in modern news, business, or scientific literature. Such access could dramatically improve their educational and professional opportunities. Quality of life for blind people is a mission of the Nat ...

DESCRIPTION (provided by applicant): The proposed project described in this grant application, combined with existing Fluorish tools, will create a robust cloud-based e-commerce marketplace for cytometry research reagents, addressing key needs in the research community. Flow Cytometry is widely used in basic and clinical research. Fluorish LLC will streamline the experimental design process and e ...

DESCRIPTION (provided by applicant): Individuals with intellectual disabilities (ID) are at higher risk for abuse than the general population. Increasing numbers of people with ID are living independently in the community with both its benefits and its risks. Many individuals with ID are subjected to physical, sexual, and verbal abuse. Some of the characteristics found in people with ID - short at ...

DESCRIPTION (provided by applicant): The purpose of the proposed project, Teacher Education: Promoting Reading Readiness (TEPRR) is to give Head Start (HS) teachers access to evidence-based instructional approaches for teaching basic language and literacyskills through high quality, easily accessible, and innovative online multimedia professional development. HS focuses on serving children from lo ...

PROJECT SUMMARY The goal of this project is to develop and disseminate the Autism Parent Trainer (APT), an online platform that provides parents of children with autism coach-facilitated instruction in how to teach new behaviors, manage problem behaviors, and learn emotion regulation and stress reduction strategies. APT will use Google+ Hangouts technology as the communication medium, which al ...