Award Data

DESCRIPTION (provided by applicant): Yecuris has developed an in vivo genetic selection system (the FRG KO mouse) that permits extensive humanization of murine liver by transplantation with human hepatocytes. This model has many potential commercial applications in drug development and testing, both in the in vivo and in vitro markets, .The mouse, however, is a small rodent and therefore the num ...

DESCRIPTION (provided by applicant): This Phase I proposal is to develop audio-tactile reading technologies. These should greatly improve access by blind people to typical graphs, charts, and diagrams in modern news, business, or scientific literature. Such access could dramatically improve their educational and professional opportunities. Quality of life for blind people is a mission of the Nat ...

DESCRIPTION (provided by applicant): The proposed project described in this grant application, combined with existing Fluorish tools, will create a robust cloud-based e-commerce marketplace for cytometry research reagents, addressing key needs in the research community. Flow Cytometry is widely used in basic and clinical research. Fluorish LLC will streamline the experimental design process and e ...

DESCRIPTION (provided by applicant): Individuals with intellectual disabilities (ID) are at higher risk for abuse than the general population. Increasing numbers of people with ID are living independently in the community with both its benefits and its risks. Many individuals with ID are subjected to physical, sexual, and verbal abuse. Some of the characteristics found in people with ID - short at ...

DESCRIPTION (provided by applicant): The purpose of the proposed project, Teacher Education: Promoting Reading Readiness (TEPRR) is to give Head Start (HS) teachers access to evidence-based instructional approaches for teaching basic language and literacyskills through high quality, easily accessible, and innovative online multimedia professional development. HS focuses on serving children from lo ...

PROJECT SUMMARY The goal of this project is to develop and disseminate the Autism Parent Trainer (APT), an online platform that provides parents of children with autism coach-facilitated instruction in how to teach new behaviors, manage problem behaviors, and learn emotion regulation and stress reduction strategies. APT will use Google+ Hangouts technology as the communication medium, which al ...

DESCRIPTION (provided by applicant): Neonatal hypoxia-ischemia (HI) remains a major cause of acute perinatal brain injury, leading ultimately to neurologic dysfunction manifesting as cerebral palsy, mental retardation, and epilepsy. Cerebral oxygen deprivation and/or reduced blood flow due to umbilical cord occlusion, prolonged labor, and/or intracranial hemorrhage produce an inflammatory respons ...

DESCRIPTION (provided by applicant): The longterm goal of this project is to utilize cytomegalovirus (CMV) vectors in the development of a therapeutic vaccine against herpes simplex virus 2 (HSV-2), the causative agent of genital herpes. HSV-2 is widely prevalent in the population causing recurrent genital lesions and significantly increasing the risk for other sexually transmitted diseases such a ...

DESCRIPTION (provided by applicant): Oral disease is a silent epidemic because of its prevalence and missed prevention opportunities. Evidence has established connections between oral-systemic etiologies, including the effects of periodontal disease (PD), and a range of health outcomes and co-morbidities across the lifecourse (e.g., adverse pregnancy and birth outcomes; early childhood carries; ...

DESCRIPTION (provided by applicant): A hallmark of virtually every cancer is aberrant epigenetic silencing of vital genes required for a normal cell cycle and genome stability (e.g. MLH1, BRCA1, VHL, p16, etc.). Loss of expression of these tumor suppressorgenes plays a critical role in cancer formation and growth. Thus, targeting this root cause of cancer has significant potential to treat and pot ...