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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A RAPID ASSAY FOR DETECTION OF DETECTION OF CARBAPENEMASE PRODUCING ORGANISMS

    SBC: CELLEX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant A recent outbreak of carbapenem resistant Enterobacteriaceae CRE associated with contaminated duodenoscopes at the Ronald Reagan UCLA Medical Center highlights the importance of early detection of these clinically significant pathogens Coincidentally the Obama Administration released The National Action Plan to Combat Antibiotic Resistant Bacteria for which ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Low Temperature Sterilization Method for Flexible Endoscopes

    SBC: Brighton Development            Topic: R

    DESCRIPTION provided by applicant Healthcare associated infections HAI are the single largest preventable medical cost in terms of both economic and humanitarian cost The significance of this problem is reflected in the $ billion annual expenditure made for healthcare associated infections in the medical community Due to the large number of procedures done each year endoscopes are associ ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Novel technologies for improved slide quality of pancreatic fine-needle aspirates

    SBC: AFFINERGY, LLC            Topic: 300

    DESCRIPTION provided by applicant Endoscopic ultrasound guided fine needle aspiration biopsy is the standard technique for diagnosis and staging of suspicious pancreatic lesions Unfortunately blood and other unwanted debris are frequently present in these fine needle aspirates thus diluting and obscuring cells of interest Subsequent slide preparations from such aspirates are suboptimal lea ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Rapid manufacturing of recombinant nucleosomes for high-throughput assays

    SBC: Epicypher, Inc.            Topic: 100

    DESCRIPTION provided by applicant Chromosomes are composed of genomic DNA and associated protein components that exert powerful regulatory effects The nm nucleosome represents the functional unit of chromatin comprising turns of genomic DNA bp wrapping an octamer of histone proteins Post translational modification PTM of the histones e g methylation acetylation or ubiquiti ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Low Cost Microphysiological System for Improved Pharmacodynamics

    SBC: SCIKON INNOVATION, INC.            Topic: 300

    DESCRIPTION provided by applicant The high failure rate of drugs in late stage development nearly is a symptom of the inadequacy of pre clinical animal models to accurately predict human biology One of the major reasons drugs fail in the clinic is inaccurate prediction of the therapeutic index which is the dose range where drugs are effective and also not toxic Failure to identify meta ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Novel tools for site-specific ablation of the mitochondrial genome

    SBC: ENZERNA BIOSCIENCES LLC            Topic: 200

    DESCRIPTION provided by applicant Millions of individuals are affected by diseases caused by mutations in mitochondrial encoded genes which lead to a diverse set of clinical disorders ranging from visual impairment optic neuropathy to accelerated aging to hypertrophic cardiomyopathy Unfortunately there are no commercially available technologies that can enable investigators to dissect the f ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Shape RNA Structure Analysis for Drug Discovery and Translational Research

    SBC: Ribometrix LLC            Topic: 200

    DESCRIPTION provided by applicant Roughly of the human genome is transcribed into RNA and in most of these RNAs complex higher order structures underlie or fundamentally affect critical biological processes RNA structures are the targets of many antibiotics and RNA structure should be further exploited in small molecule drug discovery efforts For example structures in the genomes of R ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. High-throughput methyltransferase assays using recombinant nucleosome substrates

    SBC: Epicypher, Inc.            Topic: 200

    DESCRIPTION provided by applicant Methylation of chromatin recruits various regulatory proteins to govern gene expression and represents the most common epigenetic regulator To understand this common mechanism for the modulation of gene expression it is important to study the interaction between human methylation enzymes and their chromatin targets histone proteins Currently the study of ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Innovating Tablet Based Cognitive Assessment for CNS Disorders of Aging

    SBC: NEUROCOG TRIALS            Topic: NIA

    DESCRIPTION provided by applicant Aging populations have become a key target for therapeutics developers particularly for indications impacting cognitive function Conditions such as Alzheimerandapos s disease and vascular dementia affect the quality of life of aging Americans largely due to their impact on cognitive function with insufficient therapeutic options Recent reports indicate tha ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Internally Calibrated Chromatin Immunoprecipitation Using Barcoded Nucleosomes

    SBC: Epicypher, Inc.            Topic: 172

    DESCRIPTION provided by applicant Chromatin immunoprecipitation ChIP is one of the core methods in the study of epigenetic regulation of gene expression Analytical methods such as qPCR microarray and next generation sequencing NGS have increased throughput but not the reliability of ChIP datasets Using state of the art reagents ChIP is at best semi quantitative and at worst unreprese ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
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