Award Data

PROJECT ABSTRACT Plastic offers several key advantages over Type borosilicate glass as a material for parenteral pharmaceutical containers e g vials and prefilled syringes Plastic is less prone to breakage and can be molded into more complex shapes with tighter dimensional tolerances than glass Additionally plastic is not susceptible to glass delaminati ...

AbstractAcute myeloid leukemiaAMLis the most common adult leukemia withnew cases expected inin the US and ayear survival rate of onlyThe primary cause of death for AML is due to disease relapseThe consequences of relapse are significant with it not atypical to see a relapse rate ofof which onlysurvive afteryearsIf clinicians could easily identify a patient s minimum residual diseaseMRDbefore the t ...

Abstract Bioluminescence imagingBLIsystems are installed in thousands of facilities and labsand with their straightforward and low cost workflow for longitudinal studiesare the most commonly used preclinical modality for assessing tumor models in rodentsThere currently is no high throughput and low cost system enabling BLI images to be combined with anatomical images of soft tissue to confirm tumo ...

DESCRIPTIONprovided by applicantGlucose homeostasis and regulation of food intake are both promoted by the secretion of gut hormones following nutrient stimulation of enteroendocrine cellsL cellsin the lower gutThis process is impaired in diabetes but is restored when delivery of dietary compounds such as amino acids and fatty acids to the lower gut is facilitatedThis effect of delivery of nutrien ...

PROJECT SUMMARY Clinical Sensors has developed a manufacturable prototype microfluidic sensor for measuring nitric oxide in whole bloodThis STTR Phase II project aims to complete several key aims necessary to commercialize this deviceincluding a clinical study where NO levels will be evaluated clinically in sepsisSepsis is the leading cause of death in non cardiac intensive care unitsICUsEach year ...

PROJECT SUMMARY ABSTRACT Persistent disease activity PDA in spite of anti vascular endothelial growth factor VEGF therapy remains a significant clinical unmet need for patients with neovascular age related macular degeneration NVAMD The purpose of this STTR Phase I grant application is to develop novel therapies that will be effective for the treatment of PDA associated with NVAMD The cu ...

PROJECT SUMMARYPairingdetailedphenotypiccharacterizationofcellswithdownstreammolecularanalysisrepresentsasignificant challengeespecially at the level of single cellsCell Microsystems has developed and commercializedthe CellRaftSystemwhich is currently the only commercially available means of imaging cells using brightfieldand or multichannel fluorescence prior to single cell isolation and downstre ...

ABSTRACT The disturbingly high rates of early and risky sexual behaviors of adolescents and the glamorization of risky sexual behavior in the media suggest the need for new evidence basedcomprehensive sex education programs for adolescentsParents serve as a major socialization agent for their teens and they can help improve adolescentsoutcomes by increasing their communication with their children ...

n psychiatry clinical judgment has been the predominant method of diagnosis The `gold standard for clinical research is the Structured Clinical Interview for DSM SCID The SCID promotes reliability but its validity is questionable There is growing recognition that biomarkers can be used to identify more homogeneous patient populations but there is substantial phenotypic discordance f ...

Project Summary Abstract Glioblastoma GBM is the most common primary brain tumor and one of the deadliest forms of cancer Standard surgery chemotherapy and radiation fail to eliminate the infiltrative invasive cancer cells Median survival remains only months Drugs that seek out the disseminated GBM cells behind the blood brain barrier will prevent the inevitable recurrence in patients ...