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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Web Software to develop an RDoC Compatible Adaptive Diagnostic Nosology the SID

    SBC: Health Outcomes Inc            Topic: 102

    n psychiatry clinical judgment has been the predominant method of diagnosis The `gold standard for clinical research is the Structured Clinical Interview for DSM SCID The SCID promotes reliability but its validity is questionable There is growing recognition that biomarkers can be used to identify more homogeneous patient populations but there is substantial phenotypic discordance f ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Personalized Neural Stem Cell Therapy for Cancer

    SBC: Falcon Therapeutics, Inc.            Topic: NCATS

    Project Summary Abstract Glioblastoma GBM is the most common primary brain tumor and one of the deadliest forms of cancer Standard surgery chemotherapy and radiation fail to eliminate the infiltrative invasive cancer cells Median survival remains only months Drugs that seek out the disseminated GBM cells behind the blood brain barrier will prevent the inevitable recurrence in patients ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Polo box PLK Inhibitors Target Tumors Resistant to ATP Competitive Compounds

    SBC: PPI PHARMACEUTICALS, LLC            Topic: NCI

    Polo like kinase PLK is a central player in regulating entry into and progression through mitosis Many studies have validated PLK as an anti tumor drug target and its inhibition is potently anti proliferative to cancer cells However recent data suggests that there are two major disadvantages of the conventional approach to blocking the kinase activity of PLK First both general kinome ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. High throughput CRISPR Cas cell line generation using the CellRaft Array platform

    SBC: Cell Microsystems, Inc.            Topic: NHGRI

    Project Summary Genome editing technologies such CRISPR Cas provide a rapid and targeted means of both knocking out gene expression and knocking in gene modifications However the current workflow required for CRISPR cell line generation relies on several technologies which reduce throughput efficiency and the overall viability of genome edited cells Cell Microsystems has developed a single ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Artificial neural networks for high performance fully automated particle tracking analysis even at low signal to noise regimes

    SBC: AI Tracking Solutions LLC            Topic: 400

    Abstract Particle tracking PT is a powerful biophysical tool for elucidating molecular interactions transport phenomena and rheological properties in complex biological environments Unfortunately PT remains a niche tool in life and physical sciences with a limited user base in large part due to significant time and technical constraints in extracting accurate time variant positional data fr ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A nucleosome sliding assay platform to screen inhibitors of SWI SNF chromatin remodeling complexes

    SBC: EPICYPHER, INC.            Topic: 200

    PROJECT SUMMARY In this proposal EpiCypher Inc will develop the first commercially available assay to monitor nucleosome remodeling a major current focus for rational drug discovery that is starved of HTS tools Nucleosomes are the basic units of chromatin made up of bp DNA tightly wrapped around an octamer of histone proteins Chromatin remodeling com ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Microarray performance enhancement using microfluidic mixing

    SBC: Redbud Labs, Inc.            Topic: 400

    ABSTRACT Microarray assays are a powerful cost effective clinical tool for discovery and diagnosis and have point of care diagnostic applications such as rapid and accurate detection of infections The application of microarray analysis to routine point of care warrants both speed and high quality of the data In conventional microarray assays analyte transport sharply limits assay performance ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of high sensitivity in vitro assay to detect DNA double strand breaks

    SBC: ScitoVation, LLC            Topic: NIEHS

    Abstract Chemical exposure resulting in DNA damage genotoxicity can lead to a number of negative consequences in human populations including germ cell mutations and cancer As a result evaluation of genotoxic potential is a priority requirement of regulatory agencies such as the EPA and FDA Predictivity of the current suite of assays is limited by species differences low sensitivity and int ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Comprehensive Near Patient Assessment of Severe Hypoglycemia in Newborns Using Low Blood Volume

    SBC: Baebies, Inc.            Topic: NICHD

    ABSTRACT Comprehensive Near Patient Assessment of Severe Hypoglycemia in Newborns using Low Blood Volume Fast Track SBIR Hypoglycemia is the most common metabolic disorder in newborns and places the neonate at increased risk of seizures and permanent brain injury The etiology of severe neonatal hypoglycemia which affects around newborns each year in the U S is complex with unde ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Ultrasound Based Device to Guide Treatment of Graft Versus Host Disease Using Skin Elasticity as a Biomarker

    SBC: Microelastic Ultrasound Systems, Inc.            Topic: 102

    Ultrasound Based Device to Guide Treatment of Graft Versus Host Disease using Skin Elasticity as a Biomarker ABSTRACT Sclerotic chronic graft versus host disease cGVHD develops in of allogenic Human Stem Cell Transplant HCT recipients and is associated with significant morbidity and mortality GVHD is treated with immunosuppression which puts patients at severe risk of infection ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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