Award Data

Project Summary Abstract Under this Fast Track proposalwe will develop Fenrockan abuse deterrent transdermal fentanyl patch based on our proprietary co crystal of naltrexoneNTXand its carefully selected conformermethyl furfuralMFFThis NTXMFFco crystalNTX Cohas the desired properties to stay in a crystalline solid form in the patch when applied to skin as intended but to dissociate to deliver NTX w ...

The purpose of this proposal is to develop an automated Auditory Brainstem ResponseABRbased neurological screening device and software module that will enhance the early detection of autism and other neurological conditionsAutism Spectrum DisordersASDhave an incidence rate ofBased onmillion births in the United States innew cases of ASD will be diagnosed from that birth cohort aloneThe practice of ...

Neonatal Abstinence Syndrome (NAS) has skyrocketed in recent years as a result of the opioid epidemic plaguing this country. Since 2000, the number of babies affected by NAS has increased nearly 5-fold. Every 25 minutes a baby is born suffering from opioid withdrawal, often prematurely with developmental problems and potential long-term adverse effects including cognitive impairment. Approximately ...

PROJECT SUMMARY Genomic instabilityinduced by DNA damageand partly mitigated by DNA repair and antioxidantsplays a critical role in the pathogenesis of many major human diseasessuch as neurodegenerationcancer and cardiovascular diseasetogether with agingThere is a critical need for automated assays that can perform these assessmentsand bring them into greater routine usewhich will help advance our ...

Leadless cardiac pacemakersLCPsrepresent a revolutionary leap forward in cardiac pacing technology via its circumvention of transvenous leadsCurrent LCP lithium CFX batteries arecc resulting in an overallcc LCP deviceThis Phase I effort will demonstrate the feasibility of acc betavoltaic battery for LCPs with ayear lifetimex lifetime of current LCP batteriesenabling LCPs with a volumetric size ofc ...

The rapid development of next generation sequencingNGStechnologies has allowed researchers to make unprecedented progress in the analysis of genomesthe results of which have profound implications for human healthThe ability to fully characterize genomes remains unrealizedhoweverdue in large part to our inability to reconcile sequence information over long distancesCurrent long readlong templateand ...

Project SummaryAn extensible analysis platform will be developed to accurately perform the automated genotyping of PCR capillary electrophoresisCEtraces for multiple disease associated short tandem repeaterSTRassaysThis study will evaluate the feasibility of developing generalizable and adaptive molecular analysis modelsand will ultimately establish a new paradigm for deep learning analytical tool ...

PROJECT SUMMARYArsenic in drinking water poses a serious health hazard to tens of millions of peopleespecially in parts of the world where the arsenic concentrations far exceed theppb guideline value set by the World Health OrganizationAccording to a recent studyapproximatelyM people in the conterminous U Suse water from domestic wellsmillion out of themillion peopleare predicted to be using wells ...

ABSTRACT Despite the overefficacy of diabetic retinopathyDRtreatmentit continues to be the leading cause of blindness in working age AmericansOvermillion adults in the US have diabetesOf thesewill develop DR andwill develop vision threatening DRVTDRCurrentlyless than half of all patients with diabetes receive the recommended annual dilated eye exam andof those diagnosed with VTDRonlyundergo timely ...

Summary Rat research models are established to investigate a broad spectrum of human health issues significant to most NIH Institutes and are reported in andgt;1.5 million publications listed on NCBI PubMed Central. Direct germline editing products and services generated by this SBIR project will streamline production of the most sophisticated, genetically designed rat models used to study gene, c ...