Award Data

Project SummaryMyocardial infarctionMIoccurs inAmericans annually accounting for a mortality ofWhile percutaneous coronary interventionPCIis invariably successful in restoring epicardial patencysignificant microvascular obstructionMVOresulting in theno reflow phenomenonNRFoccurs frequently which significantly impacts mortality and the development of CHFCurrent devices are only partially effective ...

Abstract Summary JANUS Research Group proposes to develop a mixed reality technology solution that will provide individual and small group training that makes use of mobile platforms such as smartphones and tablets to support e learning of health and safety issues related to hazardous radiological material for first responders Our proposed approach leverages the capabilities of modern mobile de ...

RNAs contain a wide variety of post transcriptional nucleoside modifications which play important roles in modulating RNA functions and are linked to various human diseases To decipher the functions of RNA modifications robust analytical tools that enable scientists to detect monitor and map RNA modifications are highly needed Unfortunately due to in vivo instability of RNAs and their non i ...

The contractor will use engineered versions of IL and GM CSF as adjuvants The engineered version of IL and GM CSF include a glycosyl phosphatidylinositol GPI anchor at the carboxyl terminal which permits their incorporation into lipid bilayers such as influenza viral like particles VLP The development of the adjuvant will be in the context of influenza in elderly populations The sp ...

Clonogneic assays measure the ability of single cells to proliferate and form a colony This process approximates closely the regrowth and recurance of tumors after treatment with radiation or chemotherapy providing a ready assay to screen for drugs that block this process Yet clonogenic assays are laborintensive and too cumbersome for high throughout screening HTS of compound libraries Here ...

Several types of cancerse gpancreatic and brain malignanciesremain extremely lethal despite the introduction of chemotherapy more thanyears agoThe hallmark of all cancers are somatic mutations which cannot be correctedIn sharp contrastepigenetic changesessential contributors to tumorigenesisare pharmacologically reversibleThe ability to remedy detrimental epigenetic alterations are opening up new ...

ABSTRACTThis application is seeking funding specifically for ChemistryManufacturingand ControlCMCof scale up production of long acting atrial natriuretic peptidedANPand its protected graft co polymerPGCexcipient for use in heart failureHFtreatmentThe extrinsic merit of this project will be the availability of cGMP grade PGC for use in prolonging the half life of various peptide drugs that are in p ...

Discriminating viral and bacterial meningitis infections with iDDS probes Confidential PI Shafer David A PhD PROJECT SUMMARY Rapid and accurate molecular diagnostics assays empower physicians to make informed treatment decisions especially when a disease state may result from variable causes that are indeterminable without such testing Meningitis may be caused by infection with microorganism ...

Blood biopsy test for pan cancer mutations with error checking probes Confidential PI Shafer David A PhD PROJECT SUMMARY GeneTAG Technology www genetagtech com has developed a series of molecular diagnostic assays for cancer and infectious diseases based on DNA amplification and proprietary detection methods Our primary system internal DDS iDDS probes comprises two interacting component ...