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SBC: PEARL DIAGNOSTICS, INC. Topic: NIAID
DESCRIPTION provided by applicant Aspergillosis is a severe fungal infection that most frequently involves the lungs in people who have immune deficiency caused by cancer chemotherapy and or transplantation Although good drugs are available establishing a diagnosis is difficult and late treatment has limited our progress in decreasing morbidity and mortality We observed that Aspergillus pol ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
Mitigation of Acute and Chronic Kidney Injuries by Systemic Infusion of Adipose-Derived Soluble Therapeutic Factor ConcentrateSBC: NeuroFx, Inc. Topic: 300
ABSTRACT Acute kidney injuryAKIis a syndrome characterized by rapid loss of the kidneyandapos s excretory functionAKI is the leading cause of nephrology consultation and results inmillion hospital admissions a yearThe socioeconomic impact of AKI is significantresulting in $billion cost to the health care systemDespite the high rate of incidence of AKIno therapy currently existsother than supportiv ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Sunomix Therapeutics Topic: NIAID
ABSTRACTA staggering number of overbillion individuals worldwide are currently infected with herpes simplex virus typeand or typeHSVandampHSVwhich cause genital herpesMost HSV seropositive individuals are asymptomaticASYMPand never have any recurrent herpetic diseaseIn contrasta small proportion is symptomaticSYMPwith frequentoften lifelong bouts of recurrent herpetic diseasea result of reactivati ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
A Novel Therapeutic that Harnesses Microtubules to Promote Cavernous Nerve Regeneration after Radical ProstatectomySBC: MICROCURES INC Topic: 300
Radical prostatectomyRPis a commonly used treatment option for localized prostate cancerUnfortunatelythe procedure carries a risk of post surgical complications including a high risk of erectile dysfunctionEDAccording to The Prostate Cancer Outcomes Studyvirtually all men experience ED after surgeryincluding a profound loss of nocturnal erectionsThe Prostate Cancer Outcomes Study further reveals t ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: AFASCI, INC. Topic: N
DESCRIPTION provided by applicant Preclinical evaluation of treatment strategies for retinal neurodegenerative diseases is highly dependent on mouse models Classical methods to assess the visual function of animals such as electroretinogram ERG which measures electrical responses in the retina do not address connections between the eye and brain or visual perception by the visual system ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: Integrated Biotherapeutics, Inc. Topic: NIAID
DESCRIPTION provided by applicant The ebolaviruses and Marburg virus MARV constitute the family Filoviridae andquot filovirusesandquot that cause severe hemorrhagic fever with human case fatalities of The current epidemic in West Africa unprecedented in terms of geographic scope and size highlights the continued need for development of therapeutics Among the five ebolavirus spe ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
Noninvasive placement and activation of deep-brain stimulating magnetic particles for reduction of drug-seeking behaviorsSBC: WEINBERG MEDICAL PHYSICS, INC. Topic: NIDA
Abstract Deep brain stimulationDBSwith implantable electrodes has been used for reduction of ethanol abuse and drug seeking behaviors in EuropeThe use of such deep brain stimulation procedures has been problematic because of concerns about invasiveness of the procedureApplicant has developed a new noninvasive method of transporting magnetic particles directly to target sites within the brainWe pro ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Blockade of histamine-releasing factor as a new prophylactic and therapeutic strategy for food allergySBC: ABWIZ BIO INC Topic: NIAID
DESCRIPTION provided by applicant The prevalence of food allergy has been dramatically increasing for the last few decades Food Allergy and Anaphylaxis Network www foodallergy org estimates that up to million Americans have food allergies Six to eight percent of children under the age of three have food allergies and nearly four percent of adults have them Signs and symptoms of food all ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: SIGNAL SOLUTIONS, LLC Topic: 100
Noninvasive Seizure Screening in Preclinical Models of Epilepsy There is an urgent need for research into treatment options for epilepsy and other seizure disordersAnimal models are increasingly used to understand disease mechanisms and to screen promising therapeutic approachesAnimal epilepsy model use typically requires expensive and labor intensive experimentationwith invasive EEG measurements ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: TYMORA ANALYTICAL OPERATIONS LLC Topic: 102
PROJECT SUMMARY Reverse phase protein arrayRPPAhas emerged as a promising antibody based highly quantitative proteomic technology suitable for profiling proteins in hundreds to thousands of patient samplesThe throughputsensitivityand cost effectiveness of RPPAtogether with its ability to deal with minuscule sample amountshave propelled applications of the technology in basicpreclinical and clinica ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health