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Award Data
The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Barcoded human cells engineered with heterozygous genetic diversity to uncover toxicodynamic variability
SBC: AMELIA TECHNOLOGIES LLC Topic: RProject Summary Current in vitro approaches for laboratory- and cell-based toxicology studies do not capture the interindividual variability in responses within the human population. Single nucleotide gene polymorphisms, gene heterozygosity, variations in gene expression and in some cases gene loss can yield highly variable responses to genotoxic compounds, ranging from hypersensitivity to complet ...
SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health -
PHASE I-TOPIC 431- DRUG DELIVERY BY ENDOESOPHAGEAL LAVAGE (EEL) TO TREAT ESOPHAGEAL CANCER
SBC: ISOLA THERAPEUTICS INC Topic: 431Cancer is the second leading cause of death in the United States and esophageal cancer has the 6th lowest survival rate for all cancers. Systemic drug therapy is first-line therapy for widely metastatic esophageal cancer, but is limited by systemic toxicity, patient eligibility, or cost. The proprietary Isola system consists of a drug delivery catheter, tubing, heating element, and a drug lavage s ...
SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Development of a selective PI3K-Akt-activating neurotrophic small molecule drug, MT-002, for the healing of corneal wounds in Neurotrophic Keratitis.
SBC: CALISTA THERAPEUTICS INC Topic: NEICalista is developing topical MT-002, a selective PI3K-Akt activator that safely restores normal wound healing in a clinically predictive animal model of Neurotrophic Keratitis (NK). NK causes progressive corneal damage that can lead to corneal perforation, ulceration and blindness. NK is caused by a loss of nerve sensation from the brain to the eye, decreasing growth factor release that stimulate ...
SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health -
Interactive Training Tool Providing Technique Feedback for COPD Medication Delivery
SBC: Koronis Biomedical Technologies Corp. Topic: RAbstract Koronis Biomedical Technologies (KBT) proposes to develop an inhaler training system for elder patients with the goal of improving the use of dry powder inhalers (DPIs) and pressurized metered dose inhalers (pMDIs). Inhalers deliver medication directly to the lungs and are widely used to treat Chronic Obstructive Pulmonary Disease (COPD) in older patients. It is also very important for cl ...
SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health -
FHIR-ed Up for Tobacco Cessation
SBC: Pro-Change Behavior Systems, Inc. Topic: NHLBISummary Tobacco use remains the leading preventable cause of death in the US, contributing to more than 480,000 premature deaths each year. The well-established Tobacco Treatment Guidelines and recently released American College of Cardiology Expert Consensus Decision Pathway for tobacco cessation treatment underscore the need to conceptualize tobacco use as a chronic substance use disorder and to ...
SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health -
Development of an application ("app") for training and assessment of home modification installations for aging in place
SBC: HomesRenewed Ventures LLC Topic: NIAABSTRACT Improper installation of a grab bar can be a greater risk to seniors’ safety than one that is not there at all. In this Phase I SBIR proposal, Homes Renewed Ventures, LLC (HRV, Washington, DC) creates an interactive mobile application (APP) will captures site specific inputs from a licensed contractor (contractor) to generate customized guidance and instructions for the proper specifica ...
SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health -
Simultaneous Targeting of Tumor and Stroma Cells to Enhance Solid Tumor CAR-T Cell Therapy
SBC: LUMINARY THERAPEUTICS, INC. Topic: 102Abstract The use of T cells engineered to express specific chimeric antigen receptors (CARs) to treat cancer has generated durable cures for many types of cancer and resulted in the first FDA approved CAR-T cell therapy to treat childhood acute lymphoblastic leukemia in 2017. Despite this success, CAR-T immunotherapies have been much less effective at targeting solid tumors. Part of this limited s ...
SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health -
Drug Discovery Pipeline Targeting Pathologically Leaky Calcium Release Channels in Age-Related Indications
SBC: Photonic Pharma LLC Topic: NIAProject Summary Photonic Pharma LLC (PP) proposes a Phase I SBIR project to launch high-throughput screening (HTS) for discovery of small-molecule allosteric inhibitors of pathologically leaky ryanodine receptor (RyR) calcium (Ca) release channels, to arrest or reverse age-related neurodegeneration, focused on Alzheimer’s disease (AD). In AD, dysregulated intracellular Ca fuels a pathophysiologi ...
SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health -
Implantable Unpinning Termination Therapy for Cardiac Arrhythmias
SBC: National Biomedical LLC Topic: NHLBIProject Summary/Abstract We propose the development and evaluation of a novel implantable low-energy device, using an innovative low-energy multi-pulse therapy, to achieve well-tolerated treatment of ventricular and atrial tachyarrhythmias. Ventricular arrhythmias (VAs) including ventricular tachycardia (VT) and ventricular fibrillation (VF) are responsible for 75-80% of Sudden Cardiac Death (SCD) ...
SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health -
Epilepsy Seizure Detection with Innovative Tripolar EEG (tEEG)
SBC: CREMEDICAL CORP Topic: NINDSPROJECT SUMMARY Electroencephalography (EEG) is an essential component in the evaluation of epilepsy, the most common serious brain disorder worldwide. Misdiagnosis of epilepsy is very common and occurs in up to 50% of the patients. Artifact contamination seriously hinders the effectiveness of EEG and is a root cause of misdiagnosis. CREmedical is developing a tripolar concentric ring electrode (T ...
SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health