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SBC: DASFANH BIOSCIENCES, LLC Topic: 400
Project SummaryCell free protein synthesisCFPSis a method of producing proteins outside living cells and has distinct advantages over traditional cell culture based protein productionIt is often difficult to maintain complex environmental condition for cell viability and the subsequent need to develop a downstream process for purification of product in traditional cell based systemsCFPSon the othe ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: XFIBRA, LLC Topic: NIDDK
DESCRIPTION (provided by applicant): Activation of hepatic stellate cells (HSC) is responsible for the development of liver fibrosis in chronic liver diseases of all causes and remarkably, HSC clearance by apoptosis may allow recovery from liver injury andreversal of liver fibrosis. There is full agreement among liver fibrosis experts that inhibiting o reversing HS activation (the therapeutic targ ...STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
SBC: SOAR TECHNOLOGY INC Topic: DHA17B002
Research has identified that handoffs are particularly important communication processes, during which communication error can lead to patient safety situations. Organizations have created standard practices and training materials to encourage teamwork communication for handoffs, however these do not necessarily capture the needs of military medicine of combat casualty care. Combat casualty handof ...STTR Phase I 2018 Department of DefenseDefense Health Agency
SBC: ADVANCED MEDICAL ELECTRONICS CORP Topic: NINDS
DESCRIPTION (provided by applicant): Stroke is the leading cause of adult disability and the third leading cause of death in the United States. Approximately 15 million people in the world, and more than 700,000 people in the United States, experience a stroke each year. Following a hemispheric stroke, motor control of extremities on one side of the body is usually affected. Many patients suffer a ...STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
SBC: DISCOVERYBIOMED, INC. Topic: NIDCD
Principal Investigators for Small BusinessDiscoveryBioMedIncDBMand Monell Chemical Senses Center Project Summary Abstract Bitter taste in foods and medicines presents a barrier to overcoming global public health challengesfood insecuritypoor nutritional healthand poor compliance with medication useparticularly among children and the elderlySugar and saltthe mainstays to address these challengesfur ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: MUVE, INC. Topic: NIDDK
DESCRIPTION (provided by applicant): It is uniformly recognized that sedentariness - the sitting disease - is bad for the health of the nation. The solution to reversing sedentariness involves devising and disseminating real-world solutions to promote day-long physical activity and help people who want to, to lose weight and improve their blood glucose, lipids and blood pressure. The Gruve is ...STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
SBC: Surface Bioadvances, Inc. Topic: NIAMS
DESCRIPTION (provided by applicant): Bacterial interference creates an ecological competition between commensal bacteria and pathogenic species. Like microbial competition via fermentation in a ripening fruit, bacterial interference via fermentation has been found in the deep-seated skin abscesses where is an anaerobic microenvironment, allowing bacteria to ferment carbohydrates to short-chain fa ...STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
SBC: HYGIEIA RESEARCH, LLC Topic: NIDDK
DESCRIPTION (provided by applicant): Diabetes has become a growing epidemic, yet treatment goals are seldom achieved, and patients endure detrimental complications. Insulin is the only dose-dependent antidiabetic medication in which most patients can accomplish balanced blood glucose levels when adequate dosages are prescribed. Nonetheless, only when insulin dosage is frequently titrated, is the f ...STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
SBC: S2 GENOMICS, INC Topic: 172
Project Summary AbstractThis project designsdevelopsand automates a novel system to process solid tissue into single cellssingle nucleiand high molecular weight DNA using disposable cartridges without user interventionThe system will support downstream single cell RNA or DNA sequencingsingle nuclei RNA or DNA sequencingand long read sequencers and optical mappingThe long term goal of the project i ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: INTELLIGENT HEARING SYSTEMS CORP Topic: NIDCD
DESCRIPTION (provided by applicant): The overall goal of this study is to develop a head tracking procedure for the automated assessment of hearing in infants using Visual Reinforcement Audiometry (VRA). The head tracking procedure will be incorporated into the Intelligent Visual Reinforcement Audiometry (IVRA) system from Intelligent Hearing Systems Corp. The IVRA system currently provides automa ...STTR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health