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SBC: NONINVASIX INC Topic: NICHD
AbstractIn newborn infants intermittent total hemoglobin concentrationTHbmeasurement represents an essential diagnostic testHoweverblood sampling in neonates results in iatrogenic anemiais a painful experience for infantsand is a tedious procedure for health care personnelBlood sampling forTHbmeasurements represents a high proportion of painful procedures required in infantsyet heel sticksthe most ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: POINT DESIGNS, LLC Topic: NICHD
The Point PartialA Ratcheting Prosthetic Partial FingerUsing Advanced Rapid Manufacturing Technology Project SummaryAbstract The goal of the proposed project is to develop a purely mechanicalratcheting prosthetic partial fingerthe Point Partialwhichhas an industry leading strength to weight ratiocan be operated unilaterallyone handedoffers anatomical rotation and flexion around the patient s proxi ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: ASPIREBIO CORP Topic: 101
PROJECT SUMMARY Opioid drugs are powerful analgesicsbut their side effect profile strongly limits their useIndeedtheir addictive properties have led to an epidemic of abuse in the US that accounts forof the global utilization of prescription opioid analgesics in the USwith a market of over $billion per yearPrevious studies have shown that the endocannabinoid neurotransmitteranandamidecontrols noci ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: LYST THERAPEUTICS LLC Topic: NHLBI
Project Description Despite significant advances in the surgical and medical management of congenital heart diseasecongenital cardiac anomalies remain a leading cause of death in the newborn periodMost severe forms of congenital heart disease require surgical interventionComplications arising from the use of currently available prosthetic materials in the form of vascular graftspatchesor replaceme ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Testing and Commercialization of a Superior Device to Maintain Perioperative Normothermia In Anesthetized PatientsSBC: Mercury Biomed LLC Topic: 300
Project SummaryAbstractThis proposal presents Phase II of Mercury Biomedandapos s plan for commercializing the new and innovative WarmSmart technology to more effectively keep surgical patients normothermicWarmSmart embodies several breakthrough concepts in bioheat transfer to manage core temperatureWe are building a costcompetitive patient warming technology that will be superior to existing tech ...STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
An innovative WGS platform for discovery, annotation, and interpretation of all forms of human genetic variation.SBC: Base2 Genomics LLC Topic: 172
PROJECT SUMMARY Modern DNA sequencing technologies have transformed our ability to interrogate human genomes in a single experimentthereby eliminating the inherent blind spots of gene panels and whole exome sequencingFurthermorerecent speed and economy improvements are driving the cost of whole genome sequencingWGSdown to that of WESthereforewe foresee a transition over the next two years to WGS a ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: DASFANH BIOSCIENCES, LLC Topic: 400
Project SummaryCell free protein synthesisCFPSis a method of producing proteins outside living cells and has distinct advantages over traditional cell culture based protein productionIt is often difficult to maintain complex environmental condition for cell viability and the subsequent need to develop a downstream process for purification of product in traditional cell based systemsCFPSon the othe ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Enhancement of the Beneficial Effects of Mesenchymal Stem Cell (MSC) Treatment by the Caveolin-1 Scaffolding Domain Peptide (CSD)SBC: LUNG THERAPEUTICS INC Topic: NHLBI
Abstract Systemic sclerosissclerodermaSScis a chronic connective tissue disease in which lung fibrosis is the most frequent cause of deathSSc and idiopathic pulmonary fibrosis are the two most common disease that falls under the interstitial lung diseasesILDa grouping of devastating diseases in which lung fibrosis leads to progressive shortness of breatha very poor quality of lifeand death within ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Ursa Analytics Topic: 400
Project SummaryDespite their many bene ts and common useprotein based drugs can elicit serious adverse side effectsMany of these side effects are believed to be caused by small protein aggregatesOne tool for measuring these particles in a high throughput fashion is Micro ow ImagingMFIMFI is commonly used in both academia and industry to characterize subvisible particlesthosem in sizein protein the ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Courier Therapeutics Inc Topic: 102
PROJECT SUMMARY ABSTRACT Systemic administration of high dose ILhas been used since thes as an FDA approved immunotherapy for metastatic cancerDespite the fact that up toof patients treated with high dose ILachieve a durablelong term responsethis therapy is rarely used today due to significant life threatening complicationsSuch complications occur due to ILactivation of vascular endotheliumresulti ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health