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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Noninvasive Monitoring of Total Hemoglobin Concentration in Neonates

    SBC: NONINVASIX INC            Topic: NICHD

    AbstractIn newborn infants intermittent total hemoglobin concentrationTHbmeasurement represents an essential diagnostic testHoweverblood sampling in neonates results in iatrogenic anemiais a painful experience for infantsand is a tedious procedure for health care personnelBlood sampling forTHbmeasurements represents a high proportion of painful procedures required in infantsyet heel sticksthe most ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A ratcheting prosthetic partial finger using advanced rapid manufacturing technology

    SBC: POINT DESIGNS, LLC            Topic: NICHD

    The Point PartialA Ratcheting Prosthetic Partial FingerUsing Advanced Rapid Manufacturing Technology Project SummaryAbstract The goal of the proposed project is to develop a purely mechanicalratcheting prosthetic partial fingerthe Point Partialwhichhas an industry leading strength to weight ratiocan be operated unilaterallyone handedoffers anatomical rotation and flexion around the patient s proxi ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Peripheral FAAH inhibitor, URB937, as an opioid-sparing analgesic for chronic pain.

    SBC: ASPIREBIO CORP            Topic: 101

    PROJECT SUMMARY Opioid drugs are powerful analgesicsbut their side effect profile strongly limits their useIndeedtheir addictive properties have led to an epidemic of abuse in the US that accounts forof the global utilization of prescription opioid analgesics in the USwith a market of over $billion per yearPrevious studies have shown that the endocannabinoid neurotransmitteranandamidecontrols noci ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Targeted LystaMab Therapy to Optimize Tissue Engineered Vascular Graft Performance

    SBC: LYST THERAPEUTICS LLC            Topic: NHLBI

    Project Description Despite significant advances in the surgical and medical management of congenital heart diseasecongenital cardiac anomalies remain a leading cause of death in the newborn periodMost severe forms of congenital heart disease require surgical interventionComplications arising from the use of currently available prosthetic materials in the form of vascular graftspatchesor replaceme ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Testing and Commercialization of a Superior Device to Maintain Perioperative Normothermia In Anesthetized Patients

    SBC: Mercury Biomed LLC            Topic: 300

    Project SummaryAbstractThis proposal presents Phase II of Mercury Biomedandapos s plan for commercializing the new and innovative WarmSmart technology to more effectively keep surgical patients normothermicWarmSmart embodies several breakthrough concepts in bioheat transfer to manage core temperatureWe are building a costcompetitive patient warming technology that will be superior to existing tech ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. An innovative WGS platform for discovery, annotation, and interpretation of all forms of human genetic variation.

    SBC: Base2 Genomics LLC            Topic: 172

    PROJECT SUMMARY Modern DNA sequencing technologies have transformed our ability to interrogate human genomes in a single experimentthereby eliminating the inherent blind spots of gene panels and whole exome sequencingFurthermorerecent speed and economy improvements are driving the cost of whole genome sequencingWGSdown to that of WESthereforewe foresee a transition over the next two years to WGS a ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Cell-free protein synthesis (CFPS) devices with high-yield for synthetic biology

    SBC: DASFANH BIOSCIENCES, LLC            Topic: 400

    Project SummaryCell free protein synthesisCFPSis a method of producing proteins outside living cells and has distinct advantages over traditional cell culture based protein productionIt is often difficult to maintain complex environmental condition for cell viability and the subsequent need to develop a downstream process for purification of product in traditional cell based systemsCFPSon the othe ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Enhancement of the Beneficial Effects of Mesenchymal Stem Cell (MSC) Treatment by the Caveolin-1 Scaffolding Domain Peptide (CSD)

    SBC: LUNG THERAPEUTICS INC            Topic: NHLBI

    Abstract Systemic sclerosissclerodermaSScis a chronic connective tissue disease in which lung fibrosis is the most frequent cause of deathSSc and idiopathic pulmonary fibrosis are the two most common disease that falls under the interstitial lung diseasesILDa grouping of devastating diseases in which lung fibrosis leads to progressive shortness of breatha very poor quality of lifeand death within ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Quantitative Biotherapeutic Particle Characterization via Deep Neural Networks

    SBC: Ursa Analytics            Topic: 400

    Project SummaryDespite their many bene ts and common useprotein based drugs can elicit serious adverse side effectsMany of these side effects are believed to be caused by small protein aggregatesOne tool for measuring these particles in a high throughput fashion is Micro ow ImagingMFIMFI is commonly used in both academia and industry to characterize subvisible particlesthosem in sizein protein the ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Immuno-oncology Strategy for Targeted Cytotoxic Lymphocyte Activation

    SBC: Courier Therapeutics Inc            Topic: 102

    PROJECT SUMMARY ABSTRACT Systemic administration of high dose ILhas been used since thes as an FDA approved immunotherapy for metastatic cancerDespite the fact that up toof patients treated with high dose ILachieve a durablelong term responsethis therapy is rarely used today due to significant life threatening complicationsSuch complications occur due to ILactivation of vascular endotheliumresulti ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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