Award Data

We will demonstrate the practical feasibility of transdermal analgesic therapy based onbuprenorphine, a potent opioid already used intravenously and intramuscularly for the relief of moderateto severe pain. Preliminary in vitro experiments have confirmed that buprenorphine can pass throughhuman skin at potentially therapeutic rates. Using BIOTEK's patented DermaPatch transdermal systemit should be ...

Deep infection following open fractures or bone surgery are a challenging orthopedic problem. The ugentamicin-impregnated PMMA cement or beads has become a successful part of the management of osteomchronic post-fracture infections, but these materials have disadvantages, such as the need for a secthe PMMA, the existence of many gentamicin-immune organisms, and highly non-uniform delivery. The obp ...

There is need for a convenient biodegradable bone substitute to support soft tissue and stimulate bWe will combine its unique BIOPORE material with the recently characterized osteogenic growth peptidthis objective. BIOPORE is a porous biodegradable material developed by BIOTEK. OGP is a 14-aminoacinormally present in serum, which stimulates proliferation and activity of osteoblasts and increasesde ...

Osteomyelitis is a serious orthopedic problem, and its prevention or treatment using systemic antibcomplications and is often unsuccessful. The use of polymethylmethacrylate beads or bone cement to dto bone sites does reduce the incidence of post- operative bone infections, but these non-porous poldrug delivery vehicles, and because they are non-biodegradable materials they cannot be used where bd ...

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