Award Data

Project Summary The Substance Abuse and Mental Health Services Administration (SAMHSA) has set guidelines for illicit drug monitoring for both screening and confirmatory tests. Point-of-care (POC) screening assays usually rely upon immunoassays that lack specificity among compounds in a given drug class. Confirmation testing usually employs chromatography coupled to mass spectrometry (MS), which i ...

Improved carnosic acid congener compounds for Alzheimer’s disease AbstractFive million Americans currently suffer the devastating consequences of Alzheimer’s disease (AD), and unfortunately, the numbers are increasing due to our aging population. While some treatments can lower disease burden, there is no cure and all patients inevitably succumb. Cost of care for treatment of AD is expected to ...

PROJECT SUMMARY/ABSTRACT Hispanic/Latino youth are at the highest risk for prescription opioid misuse for pain indications amongst all minority populations in the United States. There are few legitimate clinical indications for prescribing opioids to children and adolescents, as early opioid use is a known “gateway” to adulthood dependence and substance abuse disorders. Cancer and major surger ...

PROJECT SUMMARY. Gene therapy offers hope to patients with sporadic inclusion body myositis (IBM). This chronic rare disease exclusively affects older adults and results from inflammation rather than genetic mutations. Thus, it cannot be treated with gene replacement or gene editing approaches yet durable solutions like gene therapies are needed to address the progressive muscle degeneration. Such ...

ABSTRACT We propose to create a modular suite of products to facilitate highly multiplexed imaging and quantita- tive analyses of individual cells in intact tissue, and cells circulating in blood to be used to establish disease status. Our imaging software analyses platform supporting interactive data visualization will connect protein-based cellular features between tissue resident cells and diss ...

This Small Business Innovation Research (SBIR) Phase I project will validate the company’s novel fire detection principle and the use of soft computing techniques by means of (1) computational experiments, and (2) a wide range of real fire and nuisance experiments on the company’s fire detector prototypes. This will allow the company to resolve any technical hurdles that may arise from the int ...

This Small Business Innovation Research (SBIR) Phase I project will develop the foundation of a fractional-calculus-based computational platform for the simulation of multiscale and multiphysics systems. This Phase I effort will focus on developing modeling capabilities for nonlinear thermomechanical fatigue and damage behavior of ductile materials and will provide important insights on both feasi ...

The broader impact / commercial potential of this Small Business Innovation Research (SBIR) Phase 1 project relates to the development and commercial utility of color-shifting security films.Such security films produce color from light reflections in three-dimensionally designed microstructure-arrays. Approximately 5% of the world trade is estimated to be impacted by counterfeit or pirated product ...

The broader impact of this SBIR Phase I project is to make the gathering of tree measurements and other field-based nature observations dramatically easier. The project involves building a mobile app that uses computer vision and augmented reality to make measuring trees much easier than using the tape measures of today, in fact it will be as simple as scanning a barcode. This will result in much ...

The broader impact of this SBIR Phase I project is the development of an integrated methodology to use resident’s experiences about flood (and other climate change) events to validate modeling in real time, inform policy, and provide design insights for infrastructure development. It provides an integrated solution for capturing the valuable information captured by people’s direct experiences ...