Award Data

DESCRIPTION provided by applicant Non Invasive Highly Specific Detection of Oxytocin in Biological Fluids Oxytocin a neuropeptide hormone plays an important role in a variety of complex social behaviors including affiliation sexual behavior and aggression It is best known for its role to facilitate the birth process through induction of myometrial muscle contractions However recent studi ...

DESCRIPTION provided by applicant Safe and reliable access to major blood vessels and internal organs will be beneficial to patients with cardiovascular disease and cancer An interventional catheter with forward viewing ultrasound imaging capability will be developed to enable image guided access to blood vessels and internal organs Phase experiments demonstrate feasibility of building a hi ...

DESCRIPTION provided by applicant Gene transfer for the treatment of cardiovascular diseases is bedeviled by inability to obtain safely and easily sufficient cardiac transgene expression Current methods of gene transfer for heart disease include intramuscular injection into heart muscle or intracoronary delivery approaches that are cumbersome to apply Consequently we have considered the u ...

Abstract The goal of this project is to validate an innovativehighly sensitive retinal eye tracking technologythe tracking scanning laser ophthalmoscopeTSLOas a prognostic and monitoring tool for neurodegenerative disordersnamely multiple sclerosisMSThe applications of effective treatments for multiple sclerosis are constrained bythe absence of methods for early detection andquantitativehighly sen ...

DESCRIPTION provided by applicant Insulin resistance IR also known as metabolic syndrome is tied to obesity and is associated with numerous modern health problems including the growing problems of type diabetes and cardiovascular disease The growing health economic and social burdens of these conditions calls for the need to develop drug treatments for IR We know from multiple lines of ...

Alzheimer s Disease AD is the most common form of dementia and the sixth leading cause of death in the US More than million people in the US currently have AD and the direct health care cost is over $ billion per year Detection of early phase of AD namely Mild Cognitive Impairment MCI can delay prevent and treat this serious disease The project will develop a clinically feasible sy ...

DESCRIPTION provided by applicant Hazardous compounds in waters and soils are subject to a complex dynamic web of interactions among physical chemical and biological constituents in the natural environment Computational modeling has been proven indispensable to hazardous substances remediation particularly integrated modeling of pollutant hydrogeological fate and transport For the first t ...

PROJECT SUMMARY The overall goal of the proposed research and technology transfer effort is to develop a low cost point of care mobile device based technology for automated identification of Stillandapos s murmur the most common innocent benign and harmless heart murmur of childhood This novel technology could reduce the current rate of over a million children unnecessarily referred to pedia ...

DESCRIPTION provided by applicant Treatment for depression is a core health disparity for Latinos in the U S Although U S Latinos are more likely than non Hispanic Whites to experience depression Alegria et al U S Latinos are less than half as likely as Whites to receive evidence based care for depression Lagomasino et al Latinos with elevated depressive symptoms are mos ...

PROJECT SUMMARY ABSTRACT Interactions between the gut microbiome and the immune system have been linked to inflammatory bowel disease IBD IBD is a chronic and progressive gastrointestinal disease characterized by uncontrolled activation of the intestinal immune system resulting in severe medical complications affecting over million patients in the United States It is a disease of high u ...