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SBC: AURITEC PHARMACEUTICALS, INC. Topic: NIAID
DESCRIPTION (provided by applicant): The broad long-term of this project is to develop methods for evaluation of adherence to intravaginal microbicide therapy for the prevention of HIV transmission. Correct determination of adherence to preventative therapies in clinical trials is essential to accurate evaluation of efficacy. A better understanding of the true adherence to a preventative therapy w ...STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
SBC: IN VITRO ADMET LABORATORIES, LLC Topic: NIEHS
DESCRIPTION (provided by applicant): The objective of our grant application is to develop an in vitro model of the blood-brain barrier and assays to examine permeability by using isolated brain microvessels. Unlike capillaries in other organs, brain capillaries establish a barrier that is largely impermeable to polar and larger chemicals, which are due to tight junctions, the absence of both f ...STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
A non-invasive, automated platform for hemodynamic assessment of patients at risk of heart failure or pulmonary hypertensionSBC: Sensydia Corporation Topic: NHLBI
PROJECT SUMMARY Heart failure (HF) and abnormal heart function directly affects 6 million people in the U.S. and is a leading cause of death. Early intervention is key to reducing mortality and morbidity, yet early diagnosis, particularly for those with asymptomatic disease, is challenging. Effective diagnosis and management of HF and accompanying pulmonary hypertension (PH) requires accurate meas ...STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
SBC: NEUROVISION IMAGING, LLC Topic: NIA
DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is a progressive and invariably fatal degenerative dementia and the most common form of dementia that currently affects over 5 million Americans. The quality of life and economic costs are significant with estimated U.S. health care payments of over 200 billion in 2012, plus unpaid care by over 15 million Americans that is valued ...STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
A Normal Paradigm to Monitor Perinatal Asphyxia Using A Combined Ultrasound-Neuromodulation and Photoacoustic-Imaging DeviceSBC: BRIMROSE TECHNOLOGY CORP Topic: NIBIB
PROJECT SUMMARYThe Brimrose Technology Corporation and partner, The Johns Hopkins University, propose using non-invasive ultrasound neuromodulation to identify hypoxic-ischemic encephalopathy (HIE) in newborns to reduce death and lifelong brain injury. HIE is the leading cause of neonatal death and impacts 2-6 of every 1,000 live births in the developed world. Our goal is to investigate and demons ...STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
SBC: Planet Biotechnology Incorporated Topic: NIAID
Antimicrobial resistance is a major public health problem worldwide Neisseria gonorrhoeae Ng the causative agent of the sexually transmitted infection gonorrhea has become multidrug resistant and has achieved superbug status Novel therapeutics against Ng are urgently needed Complement C is a key arm of innate immune defenses A mechanism used by several pathogens including Ng to esca ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: ADVANCED BRAIN MONITORING, INC. Topic: NIMH
DESCRIPTION (provided by applicant): Neurologic disorders frequently affect everyday functioning. However, clinicians and researchers have had limited success in predicting who will, or will not, succeed at real-world tasks, since most assessments rely ontesting from in a controlled environment (clinic, laboratory) to predict performance in the less controlled and more chaotic real world. Research ...STTR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
SBC: ADVANCED BRAIN MONITORING, INC. Topic: 105
DESCRIPTION provided by applicant In Phase our team was able to enhance the ABM B Alert system for use in on the road evaluations by reducing the overall profile of the hardware system introducing real time commenting for marking events in real world activities and assessing and confirming current artifact rejection algorithms for sufficiency in real world environments In addition the ...STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
SBC: OSSIUM HEALTH INC Topic: NHLBI
PROJECT SUMMARY Mesenchymal stem cells (MSC) are in clinical development for cardiovascular, neurologic, orthopedic, and other indications. Ossium is developing a novel source of MSC from vertebral bodies (vbMSC). Genetic modification of vbMSC using lentiviral vector (LV) has the potential to improve the therapeutic potential. Understanding how genetic modification might alter the vbMSC phenotype ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: NOVORON BIOSCIENCE INC Topic: NIA
7. Project Summary Alzheimer’s disease (AD) is the most common cause of dementia and is a growing problem as populations age. More than 25 million people are affected by dementia worldwide with most suffering from AD. AD is characterized by the presence of plaques of insoluble amyloid-beta (Aβ) and tangles of hyperphosphorylated aggregates of the cytoskeletal protein, tau. Thus far, most AD tre ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health