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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. The Development and Systematic Evaluation of an AI-Assisted Just-in-Time-Adaptive-Intervention for Improving Child Mental Health

    SBC: Colliga Apps Corp.            Topic: 104

    PROJECT SUMMARY/ABSTRACT Early childhood mental health problems constitute a significant public health concern with wide-ranging impacts on functioning both concurrently and later in life. Although childhood mental health is influenced by a variety of factors, the quality of relationships with caregivers plays a critical role. Critical, coercive, and conflictual parent- child interactions have bee ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Detecting Arch Instability in Charcot Neuropathy

    SBC: INNOVATIVE SCIENTIFIC SOLUTIONS INC            Topic: NIDDK

    AbstractCharcot neuropathy (CN) is a serious complication resulting from poorly controlled diabetes and peripheral neuropathy that leads to the collapse, and ultimately the breakdown, of the midfoot. Charcot occurs in approximately 0.08% of the general diabetic population, however the prevalence increases to 13% in high-risk diabetic patients [1,2] and even 35% in patients with polyneuropathy in i ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Sorting live cells using RNA-targeting CRISPR-Cas9 (RCas9)

    SBC: DAHLIA BIOSCIENCES, INC.            Topic: 172

    Project Summary/Abstract Transcriptomic-based approaches, and in recent years, single-cell RNA sequencing, are revolutionizing our understanding of cellular heterogeneity, opening up a new route to identify novel cell markers at unprecedented scale across many different cell types. ​RNA-based live-cell sorting opens up andgt;99% of the marker space to enable higher specificity cell sorting. Howe ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES

    SBC: Enspire Bio, Inc.            Topic: NIEHS

    AbstractImpaired mitochondrial respiration plays a key role in metabolic, cardiovascular, and aging-related diseases. However, mitochondrial respirometry analysis currently requires processing of the living tissue sample within an hour after being taken from the patient. This requirement makes respirometry analysis largely unfeasible to standard clinical practice and clinical studies. We invented ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Broad Spectrum Bitter Taste Antagonists Discovery

    SBC: DISCOVERYBIOMED, INC.            Topic: NIDCD

    Principal Investigators for Small Business: DiscoveryBioMed, Inc. (DBM) and Monell Chemical Senses Center Project Summary Abstract Bitter taste in foods and medicines presents a barrier to overcoming global public health challenges: food insecurity, poor nutritional health, and poor compliance with medication use, particularly among children and the elderly. Sugar and salt, the mainstays to addres ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Nucleic acid-based formulation of cytomegalovirus-vectored HIV vaccines

    SBC: TENDEL THERAPIES INC            Topic: NIAID

    This grant is for translational development of a scalable, nucleic acid-based formulation of cytomegalovirus-vectored vaccines that can be distributed without a cold chain. HIV candidate vaccines that use cytomegalovirus (CMV) as delivery vector and immunomodulatory adjuvant have shown extraordinary promise. In our preliminary work, for example, a rhesus cytomegalovirus-vectored SIV vaccine lackin ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. High Density Cell Respirator (HDCR) for the production of vectors, viruses and vaccines

    SBC: XDemics Corporation            Topic: NCATS

    PROJECT SUMMARY/ABSTRACT This Phase I/II STTR Fast Track proposal responds to the call from the 2018/2019 NCATS SBIR/STTR Research Priorities to develop technologies so that “new treatments and cures for disease can be delivered to patients more quickly”. The production of life-altering gene editing vectors, cancer killing viruses, and life- saving vaccines currently depends on traditional cel ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Wireless withdrawal detection and monitoring system for neonatal abstinence syndrome.

    SBC: REKOVAR INC            Topic: NIDA

    PROJECT SUMMARY Neonatal abstinence syndrome (NAS) is an opioid withdrawal syndrome that develops shortly after birth to in utero-exposed neonates. The cost of NAS is high: newborns with NAS are typically receive care in the Neonatal Intensive Care Unit (NICU), where the daily cost of care is high. Nearly 22,000 infants are born with NAS each year at a cost of $1.5 billion1. Moreover, medication-b ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Recombinant Fc fusions for treatment of uropathogenic E. coli

    SBC: Planet Biotechnology Incorporated            Topic: 300

    Urinary tract infections (UTIs) are among the most common bacterial infections, affecting 150 million people worldwide each year. In the USA, community-acquired UTIs account for about 11 million cases each year that cost the U.S. public health budget $5 billion annually. Uropathogenic Escherichia coli (UPEC) accounts for up to 80% of UTIs. While UTIs are currently treated with antibiotics, the fre ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. A Novel Therapeutic Agent for the Treatment of Gram-positive Infections

    SBC: Sano Chemicals, Inc.            Topic: NIAID

    Project Summary The work described in the application is necessary for furthering the development of a new therapeutic for treating Gram-positive infections. Preliminary in vitro and in vivo activity studies of novel analogs of mutacin 1140 suggest that they hold great promise as an antimicrobial product for clinical use. Mutacin 1140 is produced by the bacterium Streptococcus mutans JH1140 and th ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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