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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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SBC: A2 Therapeutics Inc. Topic: NHLBI
Project Summary Several diseasesincluding endotoxemiaand sepsis can cause disseminated intravascular coagulationDICDIC can induce the formation of microvascular thrombicausing organ failure and death in the absence of the appropriate treatmentTo datethere are no drugs to treat DICand several reagents have been tested buttheir strong doses can lead to severe bleedingsignificantly diminishing their ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: AXCEND LLC Topic: R41
Project Summary Abstract Point of carePOCtesting of clinical samples for the presence of illegal substances and their metabolites is important for monitoring substance use disordersemployment screeningand legal matters relating to drug abstinenceTypical immunoassay screening methods suffer from higher false testing rates and do not provide quantitative informationConfirmatory tests that are used f ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Overcoming anti-PD-1 resistance by systemic delivery of an oncolytic adenovirus that targets TGF-betaSBC: Multivir Inc. Topic: 102
Project Summary The overall goal of this proposal is to test a novel systemic Adenoviral therapy that targets transforming growth factorTGFand reverses anti PDresistance to treat advanced breast and lung cancersThis STTR grant application illustrates the synergistic relationship between DrPrem Sethinventor of a novel TGFdecoyand MultiVir Inca leader in clinical development of gene based therapeuti ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Myolex Inc Topic: NIAMS
PROJECT SUMMARYAcute compartment syndromeACSremains one of the most devastating and often overlooked traumatic musculoskeletal disorders in clinical practiceIn this conditionpressure increases in one of the body s spacelimited compartmentsdue most commonly to direct trauma or bone fractureresulting ultimately in an ischemic injury to all of the compartment s contentsincluding muscle and nerveOnce ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: FieldLine Inc. Topic: 101
Abstract During Phase Iwe will test the feasibility of developing a magnetographic camera technology as a new tool in neuroscience to facilitate the detailed analysis of electrical currents in diverse neuronal circuitsInstead of photographic imagesthe camera will produce single shot images of the magnetic fields from in vivo samples of interestsuch as a patch of the grey matter in the cerebral cor ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: TDA RESEARCH, INC. Topic: 102
Project Summary AbstractDevelopment of a Nerve Cuff Electrode from Soft and Elastomeric Conducting Wires STTR Phase I ApplicationPIBrady ClapsaddleTDA ResearchIncBio electronic interfaces are used in a wide array of applications for recording and providing electrical impulses to treat diseaseOne common interface device for the PNS is the cuff electrodeCurrent cuff electrodes have many failure mode ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: abSynapTex, LLC Topic: NIA
Project SummaryThe objective of our proposed research is to develop a water soluble molecule that can reduce the levels of amyloid betaAand Drpand prevent abnormal interactions between Aand Drpin Alzheimers diseaseADaffected neuronsOur previous AD studies foundincreased production and accumulation of Aand increased expression of Drpandan abnormal interaction between Aand Drpin AD neurons that was ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: BIOINVISION INC Topic: NHLBI
System independent quantitative cardiac CT perfusion Summary BioInVisionIncand Case Western Reserve University researchers will develop software for quantitative analysis of cardiac CT perfusionCCTPcreating an important tool for evaluation of cardiovascular diseaseWith this productcardiologists will be able to identify functional flow deficits in coronary artery territoriesWhen one combines functi ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Development and non-clinical GLP testing of a new anti-arteriosclerosis gene therapy delivered by engineered adeno-associated viral vectors.SBC: KIROMIC BIOPHARMA INC Topic: NHLBI
AtheroSclerotic CardioVascular DiseaseASCVDis caused by inflammation within arteriesWhite blood cells enter the arterial wallsmacrophages become engorged with lipid cholesterol and summon other inflammatory cells to form plaques which ultimately rupture or occlude the arterykilling down stream tissuee gheart attackASCVD remains a major cause of morbidity and mortality of the elderlyCoronary artery ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: FIREBIRD BIOMOLECULAR SCIENCES LLC Topic: 400
Create Ultralong DNA Constructs in One Assembly Step Firebird Biomolecular Sciences LLCSteven ABenner Foundation for Applied Molecular EvolutionShuichi Hoshika AbstractFrost andampSullivan found aglobal market for DNA oligos at $million$million for genesPrivate investment in DNA synthesis companies like TwistGinkgoand DNA Script give collective valuations of several billion dollarsFederal public i ...STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health