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SBC: BERTEC CORP Topic: NIA
Falls are a significant source of early morbidity and mortality in the aging population, yet the neurological,sensory, and motor changes that lead to increased fall risk often escape early identification and intervention. Vital signs are commonly used in clinical settings to assess the cardiovascular system (blood pressure, heart rate), immune system (body temperature), and the respiratory system ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: MICROPROBES FOR LIFE SCIENCE INC Topic: 101
Project Summary Abstract The brain is by far the most complex and heterogeneous organ in the human bodyFor yearsthere has been a growing and unmet need to develop multielectrode arrays for neurotransmitter sensing in multiple brain regions simultaneouslyDisparate brain regions such as the nucleus accumbensstriatumprefrontal cortexhippocampusand others have been widely known to have greatly varying ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: CREATV MICROTECH INC Topic: NIDCR
AbstractIf there were a simple and accurate means totake the pulseof a toothi efunctionally similar to a pulse oximeter that could be clipped on a tooth rather than the tip of a fingerthe quality and cost of dental care would be significantly improvedThe ability to measure dental pulp blood flow provides the most direct means to determine the viability of a tooth and is a vital piece of informatio ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: LYST THERAPEUTICS LLC Topic: NHLBI
SUMMARY Despite significant advances in the surgical and medical management of congenital heart diseasecongenital cardiac anomalies remain a leading cause of death in the newborn periodMost severe forms of congenital heart disease require multiplestaged surgical interventionsA significant source of the heightened morbidity and mortality associated with these operations is the development of cardia ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: SensoDX II, LLC Topic: NIDA
Abstract Opioid abuse disorder (OAD) affects 2.1 million of Americans annually resulting in overdoses numbering in the tens of thousands and skyrocketing rates of mortality. In addition to its enormous social impact, OAD carries a multi-billion-dollar price tag that includes $78.5 billion, specifically for health care and other costs related to prescription opioid abuse and misuse. Although effect ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: GalaxyWorks LLC Topic: NHGRI
Project Summary Galactic Core LLC aims to develop a robust, scalable, and managed service for performing enterprise-grade biomedical data analysis. The service will be based on the popular open-source Galaxy application (https://galaxyproject.org/), offering unlimited data storage and compute capabilities with an extremely powerful, flexible, and collaborative environment for analyzing data. ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
Preclinical studies to validate the efficacy of novel mechanism-of-action small molecule inhibitors to treat Duchenne muscular dystrophySBC: RIDGELINE THERAPEUTICS LLC Topic: NIAMS
Progressive muscle weakness and degeneration is a hallmark of Duchenne muscular dystrophyDMDIn DMD patientsthe lack of dystrophin reduces muscle fiber structural integritymaking muscles vulnerable to persistent injury and damageRepairing these damaged muscles requires the continual activation of muscle stem cellsmuSCwhich leads to muSC dysfunction and senescenceand ultimately the muscle degenerati ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
STTR Phase I Development of Novel Antibacterial and Antifungal Bioadhesive Biomaterials for Diabetic Skin Wound HealingSBC: DYNAMIC ENTROPY TECHNOLOGY, LLC Topic: NIDDK
Abstract Diabetic ulcers or pressure ulcers are common for patients with diabetesspinal cord injuriesetcWithout proper managementsuch wounds often lead to infections such as osteomyelitis or sepsisresulting in high mortality and morbidityIn addition to bacterial infectiondiabetic patients are also more susceptible to cutaneous fungal infectionsAdvanced wound dressings and advanced wound therapies ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: CLEARNANO INC Topic: 400
SummarySystemic lupus erythematosusSLEor lupus is an autoimmune disease that impacts more thanmillion people worldwideincludingmillion AmericansNearlyof these patients will develop lupus nephritiswhich can cause kidney failureAs a resultits financial burden to individual patient can reach $yearmuch higher than many other diseases because of kidney transplantationAlthough early treatment of lupus n ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: SANERON CCEL THERAPEUTICS, INC. Topic: 999
ABSTRACT SUMMARY In previous studies we identified novel non hematopoietic umbilical cord blood stem cellsnhUCBSCsthat could be expanded to high passages and exhibit restorative properties following ischemic brain injury repairWe found that the high passaged cells were equivalentif not even betterthan the low passaged nh UCBSCsThis finding suggests that these cells can serve as a source of highly ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health