Award Data

THE OVERALL GOAL OF THIS PROJECT IS TO DEVELOP A HIGH-SPEED AUTOMATED PROTEIN SEQUENCER EMPLOYING HIGH-PERFORMANCE PACKED CAPILLARY LC SEPARATION, IMMOBILIZED ENZYMES, AND ELECTROSPRAY MASS SPECTROMETRY. THIS SYSTEM SHOULD PROVIDE MOLECULAR WEIGHT AND SEQUENCE INFORMATION USING SAMPLE AMOUNTS IN THE 1-10 PMOL LEVEL AND COMPLETE SEQUENCES AT THE 10-100 PMOL LEVEL. THIS NEW SEQUENCER SHOULD BE TECHN ...

RECENT PUBLICATIONS SUGGEST THE FEASIBILITY OF DEVELOPING A SIMPLE, SELF-CONTAINED KIT TO TEST FOR ANTIBODY TO THE HUMANIMMUNODEFICIENCY VIRUS (HIV). DURING PHASE I, IT IS INTENDED TO EXPAND THE PRELIMINARY STUDIES UTILIZING DOT-BLOT TECHNOLOGY TO DEVELOP A RAPID, SPECIFIC, AND SENSITIVE TEST FOR DETECTION OF HIV ANTIBODY THAT MAY BE PUT INTO KIT FORM FOR USE IN THE NONLABORATORY SETTING (E.G., PH ...

THE PHASE I OBJECTIVE IS TO DESIGN A BIOFEEDBACK APPARATUS FOR THE HOME TREATMENT OF NOCTURNAL BRUXISM AND TO CONDUCT A PILOT STUDY ON ITS EFFECTIVENESS. THIS APPARATUS WILL CONSIST OF A BRUXISM SENSOR AND RADIO TRANSMITTER THAT CAN BE INTEGRATED INTO ANY CUSTOM DENTAL ACRYLIC SPLINT. WHEN A BRUXING EVENT IS DETECTED, A RADIO SIGNAL PROPORTIONAL TO BRUXING FORCE TRIGGERS A NIGHTSTAND ALARM. THE NI ...

CURRENT GAS MEASUREMENT TECHNIQUES ARE INADEQUATE TO DETECT GASES USED IN CHEMICAL WARFARE WITH ENOUGH ACCURACY AND RELIABILITY IN THE HOSTILE WAR ZONE ENVIRONMENTS. IT IS NECESARY TO HAVE A SENSOR THAT WILL PROVIDE INSTANTANEOUS AND CONTINUOUS MEASUREMENT OF THE POISONOUS GASES. IT MUST OPERATE IN A HOSTILE ENVIRONMENT, INCLUDING THOSE OF HIGH SMOKE, DUST, AND OTHER VAPER/PARTICULATE CONTAMINATIO ...

THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A HIGH-PERFORMANCE INSTRUMENTATION SYSTEM FOR MULTIPLE-CHANNELNEURONAL WAVEFORM ACQUISITION AND DATA REDUCTION. THE SPECIFIC AIMS OF THIS PROJECT ARE TO: (1) INVESTIGATE THE ORGANIZATION AND CONTROL OF MULTIPLE DIGITAL SIGNAL PROCESSORS IN A MICROPROCESSOR SUBSYSTEM CAPABLE OF ACQUIRING UP TO 64 CHANNELS OF SIGNALS AND REDUCING THE NEURONAL SP ...